National Cancer Institute, Research Contracts Branch, PSCS, 6120 Executive Blvd, Eps/room 638, Bethesda, MD 20892-7227

66 -- SERIES 200 AUTOSAMPLER SOL RFQ70030-ns DUE 022497 POC Patricia Haun, Contracting Officer, 301-496-8613 the National Cancer Institute(NCI) Laboratory of Molecular Carcinogenesis is centered on a multifaceted study of cytochrome P450. The cytochrome P450 research includes the areas of molecular biology, genetics, protein chemistry, enzymology and nonoclonal antibody. We propose buying from Perkin-Elmer, 850 Lincoln Centre Drive, Foster City, CA the following items. The Series 200 Autosampler; Model 970A Interface, 20-bit, dual channel, Model 785A uv/vis detector, Turbolon Spray and APCI-Heated Nebulizer. All items shall be supplied and installed by a single contractor having trained service engineers with experience in interfacing to ensure compatibility with an existing Perkin-Elmer API 100B-001 mass spectrometer. The liquid chromatography autosampler shall accommodate 96 well plates, and be controlled by an existing MacIntosh computer and interface with an existing Perkin-Elmer API 100B-001. The UV/VIS detector shall be capable of operating with a microbore HPLC pump down to 10 ul/min and have the UV/VIS signal interfaced to a MacInstosh computer for display with mass spectral data generated by the existing Perkin-Elmer API 100B-001 mass spectrometer. The Turbolon Spray and Atmospheric Pressure Chemical Ionization Heated Nebulizer interfaces shall make use of a curtain gas for desolvation, be capable of operating in alternating positive iion, mode negative ion mode, and collision induced dissociation (CID) mode to provide structural, and be controlled by a Government owned MacIntosh computer. Curtain gas is required for complete operation of the existing Perkin-Elmer API 100B-001 mass spectrometer. The Turbolon Spray source when connected to the bench top API 100B-001 mass spectrometer shall be capable of generating a mass spectrum for Bovine Serum Albumin (BSA) and IgG antibodies that cover them/z range of 300 to 3000. It is the Government's belief that these requirements can only be met by Perkin-Elmer Sciex Instruments. This is not a formal solicitation. However, concerns that respond to this notice mustfurnish concise responses directed specifically to the requirements mentioned above. Sources demonstrating the capability to accomplish the above shall supply pertinent informationn in sufficient detail to demonstrate that ability to perform. Information furnished shall include enough material to perform a proper evaluation. Respondents will not be notified of the evaluation results. Information must be received within 20 days of the publication of this notice. See Note 22. (0030)

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