National Cancer Institute, Research Contracts Branch, TCS, 6120 Executive Blvd, Room 603, MSC 7220, Bethesda Md 20892-7220

R -- TECHNICAL AND SCIENTIFIC SUPPORT AND MANAGEMENT FOR THE PROJECT, SOL N02-CB-77032-08 DUE 041497 POC Todd C. Cole, Contract Specialist, (301)435-3822 or Nancy E. Coleman, Contracting Officer, (301) 496-8620, or FAX (301) 402-6699 E-MAIL: Todd Cole, colet@rcb.nci.nih.gov. One five-year incrementally funded contract is expected to be awarded in order to assist the Radiation Effects Branch, Division of Cancer Biology, National Cancer Institute (NCI). The Radiation Effects Branch is seeking scientific, medical and technical support services for its international collaborative program on evaluation of the radiation-induced effects resulting from the accident at the Chernobyl Nuclear Power Plant on thyroid diseases, especially thyroid cancer, among children exposed to radioactive fallout in Belarus and Ukraine and on leukemia and other hematologic diseases among Ukrainian liquidators (also known as the clean-up workers) who worked at the plant at the time of the accident or performed cleanup work within five years thereafter. NCI is seeking scientific, medical, technical and logistical services in support of NCI staff in their project management tasks, and in their interaction and collaboration with Belarussian and Ukrainian colleagues in implementing three bilateral research protocols covering epidemiological, clinical and radiation dose reconstruction studies in Belarus and Ukraine on radiation-induced thyroid cancer and leukemia, including assessment of the risk for these diseases as a function of radiation dose, sex and age at the time of the accident. This effort will include the estimation of a large number of individual thyroid and bone marrow doses by means of physical and biodosimetric techniques. The primary effort will focus on the identification of American scientists and physicians who will constitute working teams in collaboration with the NCI to work with Belarussian and Ukrainian investigators. It is expected that with few exceptions the professional personnel constituting these teams will have had previous experience in working together on similar projects. Areas of demonstrated expertise must include the following: radiation epidemiology of cancer, ultrasonography as applied to detection of radiation-induced thyroid tumors, diagnosis of (and changes in morphology and function due to) radiation-induced thyroid disease, diagnosis and etiology of radiation-induced leukemia/lymphoma and other hematologic diseases, radiation pathology, statistical analysis and quality control of data, specific clinical assays, radiation dosimetry and dose reconstruction, risk analysis, etc. Special attention will be given to quality control measures for all procedures and findings. An additional secondary effort is expected to provide logistical support for various scientific meetings, for the coordination of travel arrangements related to or resulting from the above activities, and for possible limited training of foreign personnel within the U.S. It is anticipated that this project will require approximately 7-8 FTEs per year during the proposed 5-year contract period. Special skills will require (1) familiarity with radioecological, radiobiological and relevant biomedical terminology, (2) prior involvement in large international multi-center, multi-disciplinary epidemiological studies, and (3) sensitivity to foreign cultural, socio-economic and political factors, and working environments. The RFP will be issued on or about March 3, 1997 and proposals will be due approximately 43 days thereafter. The proposed contract's SIC code is 8733 ($5.0M). (0043)

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