National Institute of Environmental Health Sciences, Contracts and Procurement Management Branch, OM, P. O. Box 12874, Research Triangle Park, NC 27709

A -- STUDIES TO EVALUATE THE TOXIC AND CARCINOGENIC POTENTIAL OF SELECTED CHEMICALS IN LABORATORY ANIMALS VIA ORAL ADMINISTRATION SODIUM CHLORATE, DIBROMOACETIC ACID, 3-CHLORO-4-(DICHLOROMETHYL)-5-HYDROXY-2-(5H)-FURANONE BROMODICHLOROMETHANE, 2-METHYLIMIDAZOLE, AND 4-METHYLIMIDAZOLE SOL NIH-ES-97-28 DUE 050997 POC Marilyn B. Whaley, Contract Specialist, 919/541-0416 The NIEHS is soliciting offers for a contract to evaluate the toxic and carcinogenic potential of selected chemicals of interest via oral administration. This project includes 2-year studies of 2-methylimidazole and 4-methylimidazole; 14-day, 90-day, and 2-year studies of dibromacetic acid and 3-chloro-4-(dichloromethyl)-5-hydroxy-2-(5H)-furanone; and, 21-day and 2-year studies of sodium chlorate and bromodichloromethane. The base contract shall consist of Phase 1 for all six chemicals to include those work activities associated with the determination of bulk chemical purity and identity, and validation of dose formulation/analysis methods, and any health and safety concerns. Upon successful completion of Phase 1, the Government may unilaterally exercise options for the conduct of 14-day, 21-day, 90-day, or 2-year studies. These studies shall be conducted according to the Specifications for the Conduct of Studies to Evaluate the Toxic and Carcinogenic Potential of Chemical, Biological and Physical Agents in Laboratory Animals for the National Toxicology Program dated August, 1992, with revisions through October 1996. Award of one cost-reimbursement, completion type contract on November 14, 1997 on an open competition basis is contemplated as a result of this solicitation. The estimated level of effort is 2,250 labor hours for the base contract and 131,203 labor hours for all options. The estimated period of performance is approximately eight months for the base contract and four years five months if all options are exercised. Interested organizations should request either a streamlined or full RFP package. If no selection is made, a streamlined version of the RFP will be provided, which will include only the Statement of Work, deliverables and reporting requirements, special requirements, mandatory qualifications, and technical evaluation criteria. After examination of these documents, any organization interested in responding to this RFP must request the entire RFP by written, telephonic ((919) 541-0416),or telefax request ((919) 541-2712). The electronic version of the CBD synopsis and the RFP (which will be available on or about March 10,1997 without the NTP specifications) is available on the Internet at: http://www.niehs.nih.gov/omcpmb/external/home.htm. All responsible sources may submit a proposal which shall be considered by the Agency. Expected release date of the RFP is March 10, 1997 with proposals due May 9, 1997. (0051)

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