METHOD FOR EVALUATING MALE FERTILITY We have discovered an acidic, 22 kD sperm protein, SP-22 (Continuation-in-Part/Patent Cooperation Treaty #PCT/US97/01725 filed January 29, 1997), that is significantly and highly correlated with fertility (p<0.0001; r^2 = 0.83) and whose concentration in an insemination sample is highly predictive of fertility. We are seeking to establish licensing or cooperative research agreements (CRADAs) for applications of this protein and/or its antibody as: 1) contraceptive agents, 2) a tool for selecting superior sires for artificial insemination, 3) a screen to select those candidates for whom assisted reproductive technologies would be most helpful or to add to sperm samples to enhance the success rates of these technologies, and 4) a screen for toxicity resulting from exposure to endocrine-disruptive agents. Those interested should contact: Ken Elstein Technology Transfer Coordinator for RTD Reproductive Toxicology Division, MD-67 National Health and Environmental Effects Research Laboratory U.S. Environmental Protection Agency Research Triangle Park, NC 27711 Phone: 919-541-3581 Fax: 919-541-4017 E-mail: elstein.kenneth@epamail.epa.gov E-MAIL: Click here to contact Technology Transfer Coordinator for RTD, elstein.kenneth@epamail.epa.gov.

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