National Institute on Drug Abuse, NIH, Contracts Management Branch, OPRM, PKLN BLDG, Room 10-49, 5600 Fishers Lane, Rockville, MD 20857

A -- MEDICINAL CHEMISTRY: SYNTHESIS OF POTENTIAL TREATMENT AGENTS FOR COCAINE ADDICTION SOL N01DA-7-8077 DUE 052997 POC Kenneth E. Goodling, Contracting Officer Phone: (301)443-6677; FAX: (301) 443-7595; Email: kg25d@nih.gov The National Institute on Drug Abuse (NIDA) is soliciting proposals from qualified individuals or organizations having the capability to design and synthesize compounds which affect primarily dopaminergic systems and either substitute for cocaine or antagonize its effects. The project shall involve the synthesis of any of the following: dopamine uptake inhibitors with a slower rate of onset than cocaine; compounds which affect dopaminergic systems through the inhibition of dopamine or serotonin trans porters; serotonin transporter selective cocaine analogs; dopamine partial agonists, agonists, and antagonists; and dopamine sparing cocaine antagonists (compounds that bind to the dopamine transporter without inhibiting dopamine uptake); and compounds selective for D1 and D3 receptors. The project shall also provide for the scale-up production, and analog synthesis, of promising compounds. The major goal of this project is to provide NIDA with a resource of novel compounds with potential use in the tr eatment of cocaine abuse. It is anticipated that six (6) cost reimbursement, term type contracts will be awarded for a period of two years, with two one-year options. This requirement is a partial set-aside for small business, i.e., three (3) of the awards will be made to small businesses. RFP No. N01DA-7-8077 will be available electronically on or about April 14, 1997, and may be accessed through the NIH Gopher and/or the Internet by using the following electronic mail addresses and instruction: 1) NIH Home Page (via the World Wide Web): Access the NIH Home Page by using http://www.nih.gov . Once you are at the NIH Home Page, select "Grants and Contracts"; select "NIH Gopher directory: listed under the "Contracts Page" section. Once at the NIH R&D Gopher, select "RFPs Available"; select "NIDA"; and select "RFP N01DA-7-8077". (URL: gopher://gopher.nih.gov:70/11/res/rd-rfp) 2) NIH Gopher: Point your Gopher client to GOPHER.NIH.GOV Port 70 (you should now be in the NIH Gopher). Select "Grant and Research Information"; select "R&D Request for Proposals (RFP)"; select "RFPs Available"; select "NIDA"; and, select "RFP N01DA-7-8077". Please note that the RFP for this acquisition will be streamlined to include only the Work Statement, deliverable and reporting requirements, special requirements and mandatory qualifications, Technical Evaluation Criteria, and proposal preparation instructions. All information required for the submission of an offer will be contained in the electronic RFP package. Following proposal submission and the initial review process, offerors comprising the competitive range will be requested to provide additiona l documentation to the Contracting Officer. Response to this RFP will be due on or about May 29, 1997. Any responsible offeror may submit a proposal which will be considered by the Government. This advertisement does not commit the Government to award a contract. See Numbered Note 2. Point of Contact: Kenneth E. Goodling, Contracting Officer Electronic Mail Address: kg25d@nih.gov Telephone: (301) 443-6677 Fax: (301) 443-7595 (0085)

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