National Cancer Institute, Research Contracts Branch, PCCS, Executive Plaza South, Room 635, Bethesda, Md 20892

A -- PRECLINICAL EVALUATION OF INTERMEDIATE ENDPOINTS AND THEIR MODULATION BY CHEMOPREVENTIVE AGENTS. SOL MAA RFP NCI CN 75031-72 DUE 061097 POC Jacqueline Ballard, Contracting Officer, NCI, RCB, PCCS, 301-435-3795 E-MAIL: Jacqueline Ballard, ballardj@rcb.nci.nih.gov. The NCI is soliciting for offerors with the capability to perform experimental animal carcinogenesis studies evaluating biomarkers and intermediate endpoints that might be used in future human clinical trials. These studies shall be performed to assess, in detail, the biomarker modulation effects of selected chemopreventive compounds. These studies shall improve biomarker sensitivity, specificity, assay methodology, and sample handling. The emphasis will be on efficient studies aimed at providing more quantitative and more validating intermediate endpoints for future human clinical trials. Master Agreements (MAs) will be awarded to all offerors who are found to be technically acceptable. This pool of offerors will be eligible to compete for Master Agreement Orders (MAOs) during the performance period of the MA. It is anticipated that 4 or 5 MAOs may be awarded each year. Only MA Holders will be issued the MAO RFP containing only requirements related to the MA with specific performance requirements and applicable evaluation criteria related to the MAO/RFP. The period of performance for the MA pool will be for five (5) years. Annual MA announcements will be issued to expand the MA pool to include new offerors. This MAA will be will be available on or before April 21, 1997, and proposals will be due on June 10, 1997. Written requests for copies of the solicitation shall be sent to Jacqueline Ballard, Contracting Officer NCI, RCB, PCCS, Executive Plaza S., Suite 635, 9000 Rockville, Pike, MSC 7226, Bethesda, Md. 20892-7226. Requests via Fax 301-402-8597 or email to ballardj@rcb.nci.nih.gov. are acceptable. No collect calls are acceptable. (0087)

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