Contracts Management Section, National Institute of Dental Research, NIH, 45 Center Drive, Room 4AN-44D, Bethesda, MD 20892

A -- IMMUNOLOGIC FACTORS IN SALIVA AND BLOOD AS DETERMINANTS OF HIV-RELATED DISEASES SOL RFP NIH-NIDR-3-97-9R DUE 061097 POC Marilyn R. Zuckerman, Contracting Officer, (301) 594-5569. The National Institute of Dental Research (NIDR) has a requirement to develop methods and assay for selected immunological and viral characteristics in the saliva and serum of members of a cohort of HIV positive U.S. military personnel. Approximately 2000 serum and 2000 saliva samples (to be furnished by the Government) will be tested for total IgG, IgM, and IgA; HIV-specific IgG, IgM, and IgA: nonspecific immune factors (lactoferrin, lysozyme and lactoperoxidase); levels of secretory leukocyte protease inhibitor; quantitative HIV virions; and infectivity of human peripheral blood mononuclear cells (PBMC). Special features of this project are the large number of samples and the need for the development of procedures to apply to saliva as the matrix and to conserve volume of specimen as much as possible. It is anticipated that one (1) award will be made as a result of this solicitation. Solicitations will be available on or about April 29, 1997, with proposals due on or about June 10, 1997. Verbal requests for the RFP will NOT be accepted; original requests MUST be submitted in writing. (0105)

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