U.S. Environmental Protection Agency, 26 W. Martin Luther King Dr., Cincinnati, OH 45268

A -- DEVELOPMENT OF TOXICOLOGICAL HEALTH / RISK ASSESSMENT PRODUCTS SOL PR-CI-97-10301 POC Billy Oden -- (513) 366-2126 WEB: Office of Acquisition Management -- Cincinnati Contracts Management Division, http://www.epa.gov/oam/cinn_cmd. E-MAIL: U.S. EPA -- Cincinnati Contracts Management Division, Oden.Billy@epamail.epa.gov. PR-CI-97-10301: The U.S. EPA has a requirement to provide support to the Office of Research and Development's National Center for Environmental Assessment at Research Triangle Park, North Carolina in two areas: (1) development of inhalation reference concentrations (RfCs), oral reference doses (RfDs), and cancer dose-response and/or unit risk assessments pertaining to long-term exposures as well as assessment of effects of acute exposures leading to derivation of acute reference exposure (ARE) values; and (2) research to improve and develop new dose-response assessment methodologies and to reduce uncertainty in existing methodologies. Chemicals for assessments will be selected by the U.S. EPA Project Officer. The data gathered in developing the RfCs, RfDs, AREs, and cancer unit risk assessments as well as data gaps identified will serve as input into research support projects. Methodologies established by the U.S. EPA to develop RfCs, RfDs, AREs, and cancer unit risk assessments will be utilized by the Contractor during the contract period. The Contractor shall be responsible for literature searches, compilation and evaluation of the toxicological literature to include data array, analysis, critique, synthesis and summary of relevant dose-response information. The Contractor shall provide the assessments in formats identified by the U.S. EPA Project Officer. The Contractor will draw upon the data generated in the assessment area to support the U.S. EPA in identifying, developing, and applying state-of-the-art methodologies to reduce areas of uncertainty in RfC, RfD, ARE and cancer unit risk assessments through statistical analyses and toxicological interpretations. U.S. EPA intends to award a Cost Plus Fixed Fee (CPFF) contract with a base period of 12 months, and a total of 4,650 Level of Effort (LOE) hours. The contract will contain options for four (4) additional 12 month performance periods, which if exercised, makes the potential total contract performance term, 60 months. The Base Period and OptionPeriod 1 will each contain options for additional quantities of 940 LOE hours. Option Periods 3, 4, and 5 will each contain options for additional quantities of 920 LOE hours. The proposed contract will be 100% set aside for small businesses. The SIC code is 8742, and the size standard is $5 million. The Request for Proposal will be issued on or about May 29, 1997, with responses due on or about June 30, 1997. Request For Proposal PR-CI-97-10301 will be available for downloading from U.S. EPA's World Wide Web (WWW) site at http://www.epa.gov/oam/cinn_cmd. A limited number of hard copies will be available for distribution. No telephone requests will be accepted. "See Note 1." (0108)

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