National Institute of Environmental Health Sciences, Contracts and Procurement Management Branch, OM, 79 T.W. Alexander Drive, 4401 Building, P.O. Box 12874, Research Triangle Park, NC 27709

A -- SUPPORT CONTRACT FOR THE NIEHS INTERAGENCY CENTER FOR THE EVALUATION OF ALTERNATIVE TOXICOLOGICAL METHODS SOL NIH-ES-97-30 DUE 061697 POC Contact Howard Hill, Contract Specialist, (919) 541-4971, Contact t Thomas Hardee, Contracting Officer, (919) 541-0429 The National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), is soliciting proposals from offerors that have these capabilities and facilities to perform the following: The major objective of this contract is to carry out scientific and scientific administrative support activities for the Interagency Center for the Evaluation of Alternative Toxicological Methods (the Center), whose goal is to promote the development, validation, acceptance, and use of alternative and other new testing methods and strategies that shall be more predictive of human health and ecological effects than currently available methods and strategies. To achieve this goal and to support the activities of the Interagency Coordinating Committee on the Evaluation of Alternative Toxicological Methods (ICCVAM), the Center shall: provide administrative support for the ICCVAM and its ad hoc Expert Working Groups, prescreen methods submitted for consideration by ICCVAM, coordinate the scientific peer review and interagency consideration of new test methods of multi-agency interest, convene expert workshops to evaluate the validation status of new methods and to identify research and validation studies needed to fill critical knowledge gaps, disseminate information on the current status of alternative test method development, validation, acceptance and use, and support the Center's Scientific Advisory Committee. In supporting the Center, the contractor shall review proposed test methods, synopsize available information, review statistical methods and comment on appropriateness and application of methods and comment on appropriateness and application of methods used, conduct literature reviews, and prepare executive summaries of reviews. As required, the contractor shall provide logistical support (e.g. local arrangements, registration materials, travel arrangements, etc.) for scientific peer reviews, workshops, etc. As required, the contractor shall provide administrative and scientific support for various entities involved in the coordinated effort. The contractor shall also be responsible for establishing and maintaining Internet list serves and web sites. The Government estimates that the project will require approximately .75 professional person years, 2.0 technical and 2.0 administrative on site person years per contract year. The estimated period of performance is 3 years, plus two (1-year) optional years. The contract will be a level-of-effort, term form cost reimbursement type contract. Requests must reference RFP No. NIH-ES-97-30 and must be directed to the office listed above. All responsible sources may submit a proposal which shall be considered by the Agency. (0108)

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