U.S. Nuclear Regulatory Commission, Division of Contracts, Mail Stop T-7-I-2, Washington, D.C. 20555

B -- DETERMINISTIC EFFECTS OF OCCUPATIONAL EXPOSURE TO RADIATION SOL RS-RES-97-051 POC Mary H. Mace, Contracting Officer, 301/415-7314/, Stephen Pool, Contract Specialist, 301/415-8168 The Nuclear Regulatory Commission (NRC), intends to negotiate a sole source contract with the University of Pittsburgh to initiate and implement, in conjunction with Branch Nuclear Number 1 -- Institute of Biophysics (FIB-1), Ozyorsk, Russian Federation (RF), recommendations resulting from a feasibility study. This feasibility study was co-developed and co-funded by the NRC and DOE in conjunction with the Russian Federation under the auspices of the Joint Coordination Committee on Radiation Effects Research (JCCRER). The objective of this feasibility study was to test the feasibility of developing a computerized database containing all of the clinical and dosimetric information collected over 45 years on the Mayak Production Association (PA), Ozyorsk, RF, worker population and analyzing it for dose-response relationships of deterministic health effects and the validation of predictive models for the consequences of significant radiation exposure. This study shows that a computerized database containing clinical and dosimetric information could be established and subsequently analyzed in order to establish dose- response relationships and validate predictive models of the consequences of significant radiation exposures. It also recommended that: (1) a comprehensive analysis of the feasibility study database be initiated; (2) the database be expanded to include all of the acute radiation syndrome, plutonium pneumonitis and chronic radiation sickness cases, as well as a group of randomly selected case-control records; (3) clinical and dosimetric analyses of the entire acute radiation syndrome and plutonium pneumonitis subsets be initiated; and (4) risk assessment models described in NUREG/CR-4214 for predicting deterministic health effects be tested. NRC knows of no other research team with the requisite qualifications and experience to conduct this work in conjunction with the FIB-1 and Mayak PA research team other than the University of Pittsburgh. This research team has been involved with assessing the adverse health effects of internal and external radiation exposure at U.S. and former Soviet nuclear facilities since the 1980's. All of the members on this research team have considerable experience working with FIB-1 physicians and scientists and Mayak PA scientists with this and other studies involving the Mayak PA nuclear workers. Equally important, the University of Pittsburgh, the FIB-1, and Mayak PA research teams have developed a delicate and collegial relationship. This relationship has been nurtured for two years. No other research team: (1) has the medical and dosimetry expertise needed, (2) has thorough familiarity with NRC health effects models, (3) has access to the FIB-1 and Mayak PA medical and dosimetry archive, and (4) has already established a working relationship with the FIB-1 and Mayak PA research team. The period of performance for this effort is 3 years. This is a notice of intent to contract only. A solicitation document does not exist. Interested parties should submit written technical documentation to the NRC describing their applicable medical and dosimetry expertise; familiarity with NRC health effects models; ability to obtain access to the FIB-1 and Mayak PA medical and dosimetry archive; and current working relationship with the FIB-1 and Mayak PA research team to satisfy NRC's needs to: U.S. Nuclear Regulatory Commission, Division of Contracts, Attn: Stephen Pool, Mail Stop T-7-I-2, Washington, DC 20555. Telephonic and/or telegraphic responses and responses providing insufficient information for evaluation will not be considered. See Note 22. (0108)

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