DHHS/National Institute on Alcohol Abuse and Alcoholism, Contracts Management Branch, Wilco Building, Suite 504, 6000 Executive Boulevard, MSC 7003, Bethesda, Maryland 20892-7003

A -- SUPPORT AND ANALYSIS FOR A STUDY ON FETAL ALCOHOL EXPOSURE IN AFRICAN-AMERICAN WOMEN SOL AA-97-10 DUE 061297 POC Matthew L. Packard, Contracts Specialist, (301) 443-1191/Edward J. Kostolansky, Contracting Officer, (301) 443-1191 WEB: NIAAA Home Page, http://www.niaaa.nih.gov. E-MAIL: Sandra Reichard, sreichar@willco.niaaa.nih.gov. The National Institute on Alcohol Abuse and Alcoholism (NIAAA) intends to negotiate a one year contract (with an Option year) with Wayne State University in Detroit, MI entitled "Clinical Support and Analysis for a Study on Fetal Alcohol Exposure in African-American Women." The purpose of this contract is to assist the Laboratory of Membrane Biochemistry and Biophysics, NIAAA in examining the effect of alcohol use during pregnancy on fatty acid composition and metabolism in the neonate. The specific aims include the study of the effect of alcohol abuse during pregnancy on normal essential fatty acid accumulation in the mother and neonate, and investigation of the mechanisms underlying this effect, i.e., determining whether changes in the levels of essential fatty acids are due to alterations in diets, decreased production, and/or increased catabolism. Authority: 41 U.S.C. 253(c)(1), as set forth in FAR 6.302-1; Wayne State University is the only responsible source having an existing clinical research program that is currently studying a large population composed primarily of pregnant African-American women, is expert in the use of research grade clinical instruments to ascertain alcohol and drug histories, and has the appropriate Institutional Review Board protocol approval already in place. Inquiries must be sent in writing; telephone inquiries are unacceptable. All responsible sources may submit a proposal which, if timely, will be considered by the Government. See Numbered Notes 22 and 26 in the Commerce Business Daily. Proposals will be due on or about June 12, 1997. (0115)

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