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COMMERCE BUSINESS DAILY ISSUE OF MAY 15,1997 PSA#1846

Cdr, U.S. Army Chemical and Biological Defense Command, Procurement, Attn: AMSCB-PCB, Aberdeen Proving Ground, MD 21010-5423

A -- STUDY OF RIBSOME INHIBITING PROTEINS SOL DAAM01-97-Q-00300 DUE 052797 POC John M. Hughes, Contract Specialist, (410) 671-2449 E-MAIL: e-mail Contract Specialist, jmhughes@cbdc7.apgea.army.mil. Identification of oligoribonucleotides that are acted upon by fungal and plant ribsome inhibiting proteins. Work shall include kinetic studies of the reaction between the identified oligmers and the hydrolytic enzymes. Ribsome inhibiting proteins shall include those from A. giganteus ans A. restrictus and those from the seeds of R. communis and A. precatorius. Four fungal genera shall be screened for the presence of types I and II ribsome inhibiting proteins. The screening protocol shall include the action on ribsomes and rRNA cleavage activity. See also numbered Note 22. (0133)

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