Cdr, U.S. Army Chemical and Biological Defense Command, Procurement, Attn: AMSCB-PCB, Aberdeen Proving Ground, MD 21010-5423

A -- STUDY OF RIBSOME INHIBITING PROTEINS SOL DAAM01-97-Q-0030 DUE 052797 POC John Hughes, Contract Specialist (410) 671-2449 E-MAIL: e-mail Contract Specialist, jmhughes@cbdc7.apgea.army.mil. This notice is a modification of previous notice W-133 SN072318. The U.S. Army CBDCOM intends to negotiate, on a sole source basis, with the University of British Columbia, Department of Microbiology and Immunology, 6174 University Blvd., V6T1Z Vancouver, BC, V6T 1Z3, Canada, for contractor effort to identify oligoribonucleotides that are acted upon by fungal and plant ribsome inhibiting proteins. Work shall include kinetic studies of the reaction between the identified oligmers and the hydrolytic enzymes. Ribsome inhibiting proteins shall include those from A. giganteus and A. restrictus and those from the seeds of R. communis and A. precatorius. Four fungal genera shall be screened for the presence of types I and II ribsome inhibiting proteins. The screening protocol shall include the action on ribsomes and rRNA cleavage activity. See also numbered Note 22. (0133)

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