National Institute of Environmental Health Sciences, Contracts and Procurement Management Branch, OM, 79 T.W. Alexander Drive, P.O. Box 12874, 4401 Building, Research Commons, Research Triangle Park, NC 27709

A -- COORDINATING CENTER FOR THE AFRICAN-AMERICAN HEREDIATRY PROSTATE CANCER STUDY NETWORK SOL NIH-ES-97-34 POC Contact Velvet M. Torain, Contract Specialist, 919/541-0440/Phillip D. Jones, Contracting Officer, 919/541-0426 The National Institute of Environmental Health Sciences intends to negotiate a contract with Howard University College of Medicine, Washington D.C. to explore the genetics of hereditary prostate cancer (HPC) in African-Americans for the National Human Genome Research Institute. Howard University will serve as a coordinating center and establish a subcontract with recruitment/collection centers to ascertain HPC subjects from the African-American community. The contractor shall establish standardized criteria for collection of genetic, clinical and epidemiological data on the study population; serve as the locus for receipt of samples from off-site recruitment centers and establish a core facility for the isolation, characterization and storage of cells and DNA for genomic and biological studies. The contractor shall prepare DNA, process samples for genotyping and provide quality control samples for genotyping and forward them to the National Human Genome Research Institute for analysis; establish and manage a steering committee for the study and arrange yearly meetings of the committee. It is anticipated that the contractor will collect a total of 100 families to participate, and generate approximately 240,000 genotypes over the life of the study. The contract will be for two years with a planned award date on or before September 30, 1997. It is anticipated that this project will require appoximately 15,600 man hours over the two years. Authority: 41USC 253(c)(1), as set forth in FAR 6.302-1 -- Only One Responsible Source. Howard University is the only predominantly African-American university to be designated a level-one research university by Carnegie Commission on Higher Education. Thus through its acedemic program of teaching, research, and service, Howard University is uniquely capable of increasing the inclusion of minorities in research study populations. Any other interested sources desiring consideration for this requirement must fully identify their interests and capabilities to the ContractingOfficer listed above. See Numbered Notes 22 and 26. (0133)

Loren Data Corp. http://www.ld.com (SYN# 0002 19970516\A-0002.SOL)