National Cancer Institute, Research Contracts Branch, Cancer Etiology Contracts Section, Executive Plaza South, Rm. 620, 6120 Executive Blvd., MSC 7224, Bethesda, MD 20892-7224

A -- EPIDEMIOLOGIC STUDIES OF THE MAYAK TECHA RIVER COHORTS IN THE RUSSIAN FEDERATION SOL N01-CP-51025-21 DUE 062997 POC Barbara A. Shadrick, Contracting Officer, 301/435-3787, fax 301/480-0241 E-MAIL: Barbara A. Shadrick, bs92y@nih.gov. The National Cancer Institute (NCI), Division of Cancer Epidemiology and Genetics (DCEG), Radiation Epidemiology Branch (REB), intends to negotiate an add-on to the above-referenced contract with the Radiation Effects Research Foundation. This objective of this additional work is to study thyroid hormone levels and thyroid disease among people exposed to I-131 during childhood. The exposed group shall include about 500 people who were born and lived in Ozyorsk, Russia in 1952-1953, the period of maximum radioactive releases from the Mayak nuclear weapons processing plant opened in Chelyabinsk, Russia in 1948. A comparison group shall include approximately 200 people who were born outside of Ozyorsk, Russia, in 1952-1953, but moved to Ozyorsk between 1968-1990, a period when the very minimal releases from Mayak had no practical effect on the city population. Data collection will include clinical exams and tests and medical record reviews. Serum levels of thyroxine, triiodothyronine, thyrotropin, free thyroxine and antithyroperoxidase antibodies (or anti-thyroid microsomal antibodies) will be assayed. Authority for this action is 41 USC 253(c)(1), as set forth in FAR 6.302-1(a)(2)(ii). (See Numbered Note 22.) All responses to this notice must be submitted in writing by mail, fax or e-mail. Collect calls will not be accepted. (0135)

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