Centers for Disease Control and Prevention (CDC), Procurement & Grants Office, Program Acquisition Branch, 255 East Paces Ferry Rd, NE, Rm 500, Atlanta, GA 30305

B -- CHRACTERIZATION OF BACTERIAL FACTORS AFFECTING THE TRANSMISSION OF MYCOBACTERIUM TUBERCULOSIS SOL 200-97-0639(P) DUE 072597 POC Barry E. Smith, Contract Specialist, (404) 842-6787 The Centers for Disease Control and Prevention (CDC) contemplates awarding one or more contracts to 1) compare the rate of transmission of strains with differing patterns of transmission in the community using animal models, including measuring the ability of the strains to form aerosols and survive in the environment, 2) investigate the kinetics and mechanisms of the virulence and pathogenicity of the outbreak strains in the mouse and guinea pig models of tuberculosis, 3) investigate the mechanisms of entry, survival, and replication of outbreak strains in human macrophages, and 4) investigate the immunoreactivity of the outbreak strains including determining the ability of the outbreak strain to induce delayed type hypersensitivity and cytokine production and to identify mycobacterial factors responsible for increased immunoreactivity. Only written requests for copies of the solicitation will be honored and may be faxed to (404) 842-6727 or E-Mailed to BAS4@CDC.GOV. Telephone requests will not be accepted. The date specified for receipt of offers will be approximately 30 days after the RFP issue date. Requests for the RFP must specify the RFP No. 200-97-0639(P). All responsible sources that meet the above requirements may submit a proposal which shall be considered by the Agency. (0160)

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