National Institutes of Health, National Institute of Allergy and Infectious Diseases, Contract Management Branch, Solar Bldg., Room 3C07, 6003 Executive Blvd. MSC 7610, Bethesda, MD 20892-7610

A -- PRECLINICAL EVAULATION OF THERAPIES FOR THE TREATMENT OF CRYPTOCOCCOSIS SOL RFP-NIH-NIAID-DAIDS-98-13 DUE 112097 POC Joyce U. Sagami, Contract Specialist, (301) 496-7118 E-MAIL: Contract Specialist, js73b@nih.gov. The Opportunistic Infections Research Branch, Therapeutics Research Program, Division of AIDS, National Institute of Allergy and Infectious Diseases (NIAID), NIH, has a requirement to develop therapies for the treatment of AIDS and associated opportunistic infections. The purpose of this RFP is to seek responsible offers for establishment of drug screening capability. To this end, this solicitation is to support activities in the microbiological and animal model testing of new candidate drugs. Performance of the Work Statement includes (a) evaluation of therapeutic agents against C. neoformans in a standardized, validated mouse model of acute cryptococcal infection of the central nervous system; (b) evaluation of therapeutic agents against C. neoformans in a standardized, reproducible and validated in vitro test system employing intact organisms; and (c) additional studies such as evaluation of drug combinations, determination of optimal dosages of therapeutic agents, and evaluation of therapeutic agents in prophylaxis protocols. It is anticipated that one (1) cost reimbursement, completion type contract (approximately 2.5 FTEs) will be awarded for a period of four (4) years, beginning approximately July 23, 1998. RFP-NIH-NIAID-DAIDS-98-13 will be available electronically on or about July 20, 1997, and may be accessed through either the NIAID Contract Management Branch (CMB) Home Page or the NIH Gopher by using the following electronic addresses and instructions: (1) NIAID/CMB Home Page (via the World Wide Web): Access by using http://www.niaid.nih.gov/contract and select the "RFPs" link. (2) To access the NIH Gopher: Point your Gopher client to GOPHER.NIH.GOV PORT 70 (You should now be in the NIH Gopher). Select "Grants and Research Information", then select "R&D Requests for Proposals (RFP)". Please note that the RFP for this procurement has been revised to include only the Work Statement, deliverable and reporting requirements, the Technical Evaluation Criteria, and the proposal preparation instructions. All information required for the submission of an offer will be contained in the electronic RFP package. Following proposal submission and the initial review process, offerors comprising the competitive range will be requested to provide additional documentation to the Contracting Officer. Responses to this RFP will be due on November 20, 1997. Any responsible offeror may submit a proposal which will be considered by the Government. This advertisement does not commit the Government to award a contract. Point of Contact: Joyce U. Sagami, Contract Specialist Electronic mail address: js73b@nih.gov Telephone: (301) 496-7118 FAX: (301) 402-0972 No collect calls will be accepted. (0177)

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