Los Alamos National Laboratory, Mail Stop C334, P.O. Box 1663, Los Alamos, NM 87545

A -- SEQUENCE COMPARISON AND ANALYSIS SOFTWARE (SCAN 1.0) SOL IPO-97-25 POC John B. Mott, Ph.D. Partnership Development and Agreements, MS C331, Tel: (505) 665-0883, FAX: (505) 667-4098, E-Mail: jb_ mott@lanl.gov. The University of California, which operates Los Alamos National Laboratory (LANL) under contract to the Department of Energy (DOE), is seeking industrial partners to participate in the commercialization of its Sequence Comparison and Analysis (SCAN 1.0) software. SCAN is a tool for searching databases of DNA, cDNA, RNA, or protein sequence information and finding matches to a target sequence. Rather than searching the databases directly, however, SCAN takes as its input the output of genetic analysis tools such as BLAST, FASTA, Smith/Waterman, and GRAIL. As its output, SCAN gives a concise report that integrates results from multiple database searches. SCAN reduces redundant matches to repetitive sequences to a short summary and provides a measure of the quality of these matches. SCAN greatly facilitates the interpretation of regions of database matches by automatically processing existing annotation associated with the matched databases sequences to characterize the regions as coding, intron, Alu, L1, EST, repetitive, vector, E.coli contamination, etc. Multiple database matches to the same query sequence region are combined into a multiple sequence alignment in the output reports. SCAN generates three output formats including HTML with World-Wide Web hot-links to public databases and is written in the "C" programming language. SCAN has many potential applications including gene identification, medical diagnostics, and drug discovery and development. Industrial partners are being sought to enter into a technology transfer agreement to commercialize this software. Partnership may include, but is not limited to, license agreements and Cooperative Research and Development Agreements (CRADAs). Prospective partners must demonstrate experience in software development and commercialization, product marketing capability, and sound financial backing. Any company that is interested in pursuing this opportunity or that wishes to receive more information concerning this opportunity should respond with a brief statement describing its technical expertise, marketing capability, financial resources, estimates of the relevant market for each specific application being considered, previous technology transfer experience (if any), and motivation for participation in the program. The statement of interest must be dated within 30 days from the date of this notice. For more information about other available technologies at LANL see the DOE Technology Information Network (DTIN) at http://www.dtin.doe.gov/. (0196)

Loren Data Corp. http://www.ld.com (SYN# 0011 19970717\A-0011.SOL)