National Cancer Institute, Research Contracts Branch, PSCS, 6120 Executive Blvd, Eps/room 638, Bethesda, MD 20892-7227

66 -- LIQUID CHROMATOGRAPHY/ATMOSPHERIC MASS DETECTION SYSTEM SOL RFQ70122-NS DUE 081297 POC Patricia Haun, Contracting Officer 301-496-8613 The National Cancer Institute (NCI) Cellular and Clinical Pharmacology Section plans to procure a liquid chromatography/atmospheric mass detection system from Waters Corporation, 34 Maple Street, Milfor, MA 01757. The Waters HPLC system is the oly system known which offers the following characteristics and associated benefits: 1) quaternary gradient flow rates from 0.03 ml/min to 5 ml/min withoutpressure pulsation or compositional ripple, which allows for a greater range of analytical conditions, including narrow-bore and micro-bore chromatography which will conserve HPLC solvents and yield greater sensitivity; 2) a pumping system be constructed with serial flow between two independently driven pump heads and a pump stroke which is automatically adjustable for optimization of flow precision at varying flow rates and allows the greatest accuracy of solvent flow which is necessary for low flow chromatography such as narrow-bore and LC/MS, 3) an integrated 4 channel vacuum degasser which eliminates the need for helium tanks for sparging, saves space and eliminates the hazard of compressed gas cylinders in the laboratory; 4) controlled by Millennium chromatography software which simplifies the transfer of related data from one computer to the other for ease in analyzing data; 5) utilization both Electro spary and Apcl interface technologies which allows for increased flexibility in sample analysis; 6) capable of detecting 10 pg of a reference standard such as reserpine, which allows for high sensitivity analysis of drug metabolites and 7) have an automated divert valve, which allows for simplified use of existing HPLC as a stand alone iinstrument when Mass Spec analysis is not required, thus preventing the dedication of an HPLC system and removes the need to purchase an additional HPLC system for future needs. This notice of intent is not a request for competitive proposals, however, if any interested party believes they can meet the above requirements, they may submit a statement of capabilities and a detailed description of the machines capabilities. Information furnished shall include enough material, in sufficient detail, to perform a proper evaluatiion of their ability to perform and must be received within 20 days of the publication of this notice. See Note 22. (0203)

Loren Data Corp. http://www.ld.com (SYN# 0386 19970724\66-0021.SOL)