National Institutes of Health; Office of Purchasing and Contracts, OPM/OD; 6006 Executive Blvd., Suite 311, Rockville, MD 20892-7058

A -- LABELING DNA OLIGONUCLEOTIDES WITH RADIOACTIVE ISOTOPES OF PLATINUM. SOL 263-95-Q(M5)-0166 DUE 080497 POC Contact Purchasing Agent Sabrina Lindsay on 301-496-3704. The Department of Nuclear Medicine, CC, NIH, is developing novel DNA-based radiopharmaceuticals for targeting eukaryotic genes using trilex-forming oligonucleotides (TFO) labeled with Auger-electron emitters (AE). Upon binding to a DNA target sequence in the genome, AE labeled TFOs introduce double-stranded breaks into intracellular DNA. The accumulation of double-stranded breaks in genomic DNA can result in deletion of the target sequence or have consequences such as the induction of apoptosis and cell death. (0206)

Loren Data Corp. http://www.ld.com (SYN# 0007 19970729\A-0007.SOL)