National Cancer Institute, Research Contracts Branch, PSCS, 6120 Executive Blvd, Eps/room 638, Bethesda, MD 20892-7227

A -- ESTIMATES OF CANCER NCIDENCE & PREVALENCE ON THE STATE LEVEL IN THE U.S. SOL NCI-RFQ-70141 DUE 082997 POC Cynthia Brown, Purchasing Agent- (301) 402-4509 Trish Haun (301) 402-4509 The National Cancer Institute, National Inst. of Health, Applied Research & Cancer Statistics Branch in the Division of Cancer Prevention and Control intends to issue a Sole Source order to Instituto Superiore Di Sanita, Rome, Italy (Drs. Riccardo Capocaccia & Arduino Verdecchia) to obtain estimates of cancer incidence and prevalence on the state level in the U.S. A statistical method for estimating chronic disease incidence and prevalence from mortality and patient survival data has been developed by researchers from the Instituto Superiore Di Sanita In Rome, Italy. This method has been applied to study cancer morbidity trends at the national level in Italy. The aim of this project is to perform a pilot study oriented to take careful modeling for selected cancer sites (i.e., female breast, prostate, and male and female colorectal cancers), geographic areas (i.e., California, Louisiana, Minnesota, and New Hampshire), and for validating model estimates with respect to the observed incidence and prevalence figures provided by cancer registries or from other sources. Drs. Ricardo Capocaccia, Arduino Verdecchia are leading experts in the development of the methods and application for estimating disease incidence and prevalence. They have an extensive list of published work in this area, appearing in major statistical and epidemiologic journals. A search of the relevant literature has indicated that the method which will be used in this pilot has not been used in the United States. Thus, the expertise and experience of these investigators, is essential to the success of this pilot program and the continued use of the method by the Government. The contractor(s) will also develop and deliver a software program which will be used by the Government. Education in the use of the software and method for furture studies by Government researches is also part of this pilot. This is not a request for quotes vendors who believe they can meet the Government requirement may submit their qualifications. The submissionmust be in writing and must contain sufficient detail so that a determination can be make regarding meeting the Governments requirements. The submission must be received by the COB August 29, 1997. No collect calls will be accepted. (0217)

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