National Institutes of Health, Office of Extramural Programs, Office of Extramural Research, PHS SBIR/STTR Solicitation Office, 13687 BALTIMORE AVE, LAUREL MD 20707-5096

A -- A SOLICITATION OF THE PUBLIC HEALTH SERVICE FOR SMALL BUSINESS S INNOVATION RESEARCH CONTRACT PROPOSALS SOL PHS 98-1 DUE 110597 POC Office of Extramural Programs, Office of Extramural Research (301) 435-2770 WEB: National Institutes of Health's "Small Business Funding Opportunities", http://www.nih.gov/grants/funding/sbir.htm. E-MAIL: PHS SBIR/STTR Solicitation Office, a2y@cu.nih.gov. THE SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM OF THE U.S. . PUBLIC HEALTH SERVICE SOL [PHS 98-1] DUE 110597 POC Office of Extramural Programs, Office of Extramural Research, (301) 435-2770. National Institutes of Health, Bethesda, MD 20892 and Centers for Disease Control and Prevention, Atlanta, GA 30305 of the Public Health Service are soliciting proposals from small business concerns that possess the research and development (R&D) expertise to conduct innovative research that will contribute t oward meeting the program objectives of the agencies. A SOLICITATION OF THE PUBLIC HEALTH SERVICE FOR SMALL BUSINESS INNOVATION RESEARCH CONTRACT PROPOSALS {PHS 98-1], with a closing date of November 5, 1997, for receipt of proposals, is or soon will be available electronically through the National Institutes of Health's "Small Business Funding Opportunities" home page at http://www.nih.gov/grants/funding/sbir.htm on the World Wide Web. A limited number of hard copies of the PHS SBIR Contract Solicitation is or soon will be available from: PHS SBIR/STTR Solicitation Office, 13687 Baltimore Avenue, Laurel, MD 20707-5096, phone: (301) 206-9385, fax: (301) 206-9722, e-mail: a2y@cu.nih.gov. Included in the Solicitation is a "Fast-Track" pilot. Fast-Track is a parallel review option available to those small business concerns (offeror organizations) whose proposals satisfy additional criteria which enhance the probability of the project's commercial success. Fast-Track offers two major advantages: (1) concurr ent peer review of both Phase I and Phase II projects and (2) minimal or no funding gap between Phase I and Phase II. A "Commitment Appendix" and a "Product Development Plan Appendix" must accompany the Phase II proposal. The SBIR program, which was initiated in 1982, was reauthorized through fiscal year 2000 by the "Small Business Research and Development Enhancement Act of 1992" (Public Law 102-564, dated October 28, 1992). The purposes of the Act are to: (a) expand and improve the SBIR program; (b) emphasize increased private sector commercialization of technology developed through federal R&D; (c) increase small business participation in federal R&D; and (d) foster and encourage participation of socially and economically disadvantaged small business concerns and women-owned small business concerns in the SBIR program. For purposes of the SBIR program, a "small business concern" is any business concern that: (a) is independently owned and operated; (b) is not dominant in the field of operation in which it is proposing; (c) has its principal place of business located in the United States; (d) is organized for profit; and (e) has, including its affiliates, no more than 500 employees. Following are the research topics identified in the SBIR Contract Solicitation [PHS 98-1]: NATIONAL INSTITUTES OF HEALTH (NIH) -- NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM (NIAAA): Development of Psychometric Techniques Tailored for the Alcohol Field (DBE); Portable Miniaturized Alcohol Monitoring Device (DBR); Devel opment of Methodology for Measuring Compliance for Medications (DCPR); Medications Development (DCPR); Evaluation of Alcohol Abuse and AIDS Prevention Programs (DCPR); Performance Indicators of Quality of Care for Alcohol Treatment (DCPR); NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES (NIAMS): Markers of Osteoarthritis; NATIONAL CANCER INSTITUTE (NCI): Innovative Approaches to Clinical Trials Informatics; NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES (NIDDK): Assays for Identification of High Risk Individuals for the Development of Insulin Dependent Diabetes (IDDM); Transplantation of Human Islets or Beta Cells; Improved Methods for Production of Clinical Gene Therapy Vectors for Diseases of Interest to NIDDK; Acute Renal Failure; New Noninvasive Body Iron Test; Mechanical Approaches to Achieving Euglycemia; Chronic Renal Failure; NATIONAL INSTITUTE ON DRUG ABUSE (NIDA): Drug Supply Services Support; Chemical Libraries for Drug Development; Analytical Techniqu es Program; Develop Animal Model(s) with Compromised Immune Function Induced by Abused Drug(s) to Screen Potential HIV/AIDS Medicating Agents; Development of a Computerized Neuropsychological Testing Program; Internet-based Research Support for Drug Abuse Researchers; Development of a Management Information System on Ethnic Specific Factors in the Etiology of Drug Abuse Among Minority Populations; Develop Prevention Research Dissemination; Design and Construction of a Multi-Environment, Multi-Choice Rodent Testing Apparatus; NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES (NIEHS): Development of a Transgenic Teleost Animal Model for Assessing Mutagenesis; Commercialization of Laboratory Methods for Assessing the Genetic Responses to Chemicals; Methods for Assessing the Estrogenicity and Other Endocrine Activity of Environmental Chemicals; Rapid Mutational Analysis of Rodent DNA Samples; High Kd Fluorescent Calcium Indicators; Development of Assay Systems for Determining the Formation of Mutagens by Prost aglandin H Synthase-2; Development of Applications of Human Breath Analysis for Metabolic Phenotyping of Individuals; Development of an EIA Kit for Determination of 2,3-Dinor-5,6-dihydroprostaglandin F2 ; Development of an Enzyme Immunoassay for Arachidonic Acid Epoxides and Diols; Detection of Mutations in Stem Cell Spermatogonia from Transgenic Mice with Integrated PhiX Vector; Development of Oligoarrays for Genotyping Human Polymorphisms Associated with Cancer Risk; Development of Embryonic Stem Cells for Experimental Studies; Development and Evaluation of Transgenic Mouse/Rat Models for Problems in Environmental Toxicology and Carcinogenesis; NATIONAL HEART, LUNG, AND BLOOD INSTITUTE (NHLBI): Computer Algorithm for the Identification of Unknown Proteins After Peptide Sequencing; Atherosclerosis Gene Discovery Program; NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE (NINDS): Development of Non-Pharmacological Therapy of Epilepsy; Anti-epileptic Drug Delivery Systems and Formulations; Portable D evices For Sleep Disorder Screening/Monitoring; Non Pharmacological Therapy of Sleep Disorders; Models for Screening Antiepileptic and Antiepileptogenic Therapy; Alertness Measures; Improved EEG/ICU/OR Interface; Improving Magnetic Resonance Imaging to Evaluate the Central Nervous System of Critically-ill Neonates; Inducible Knockout Technology; Genome Scanning; Direct Gene Transfer; NATIONAL CENTER FOR RESEARCH RESOURCES (NCRR): General Software Tools for Biomedical Research; Enhancement and Support of the SAAM II Software; CENTERS FOR DISEASE CONTROL AND PREVENTION (CDC) -- NATIONAL IMMUNIZATION PROGRAM (NIP): Means to Decrease Trauma Associated with Children Rec eiving Parenteral Injections; Assay to Detect Minimal Infectious Dose of HBsAg or Blood Surrogate; Safe, Needle-free, Liquid Jet Injector for Routine Immunization Clinics; Needle-free, Fast, Liquid Jet Injector for Mass Immunization Campaigns; Needle-less Device to Deliver Powdered Measles Vaccine into Skin or Mucosa; PUBLIC HEALTH PRACTICE PROGRAM OFFICE (PHPPO): Improving Public Health Through Geographic Information Systems; NATIONAL CENTER FOR CHRONIC DISEASE PREVENTION AND HEALTH PROMOTION (NCCDPHP): De velopment of New Methods to Quantify Lipoprotein Subfractions. The SBIR Contract Solicitation PHS 98-1, including proposal forms, is or soon will be available electronically through the National Institutes of Health's "Small Business Funding Opportunities" home page at http://www.nih.gov/grants/funding/sbir.htm on the World Wide Web. A limited number of hard copies of the PHS SBIR Contract Solicitation is or soon will be available from: PHS SBIR/STTR Solicitation Office, 13687 Baltimore Avenue, Laurel, MD 20707-5096, phone: (301) 206-9385, fax: (301) 206-9722, e-mail: a2y@cu.nih.gov. (0230)

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