National Cancer Institute, Research Contracts Branch, PSCS, 6120 Executive Blvd, Eps/room 638, Bethesda, MD 20892-7227

A -- RESEARCH 7 DEVELOPMENT SOL NCI-RFQ-70183 DUE 091697 POC Cynthia Brown, Purchasing Agent, 301-402-4509, Trish Haun, Contracting Officer This is a combined sole source synopsis/solicitation. The National Inst. of Health, National Cancer Intitutes, Division of Cancer Prevention and Control, intends to contract on a sole source basis with the Cancer Institute, Chinese Academy of Medical Sciences, Beijing, People's Republic of China. The purpose of this procurement is to determine if supplementation with multiple vitamin-minerals reduces the incidence and mortality of esophageal and/or other cancers, and total mortality. The highest worldwide rates of essophageal cancer occur in Linxian, China where cumulative death rates to age 75 for this cancer exceed 20%. Since 1985 the NCI has been collaborating with the Cancer Institute of the Chinese Academy of Medical Sciences (CICAMS) to conduct the nutrition intervention trials in Linxian, China and to follow trial participants in the post-intervention period (as well as continue to store and utilize biologic samples collected during the trials to further study the etiology and potential methods to prevent esophageal and other upper gastrointestinal cancers). In order to further elucidate the role of nutrition and other environmental and genetic factors in the etiology and prevention of esophageal and other upper gastrointestinal cancers. NCI now requires: (1) determination of the vital status and cancer status of all nutrition intervention trial participants; (2) collection and storage of all available diagnostic materials for intervention trial participants; (3) continued storage of all existing biologic samples collected during the nutrition intervention trials and provision of record of daily freezer and ambient temperatures in the freezer storage room; (4) development of a current inventory of all existing biologic samples collected nutrition intervention trial participants; (5) development of a plan for the use of the biologic samples; and (6) delivery of biologic samples in accord with the plan. This is not a request for competitive proposals; no solicitation will be issued. However, vendors who believe they can meet the Governments requrements may submit their capability statements. Any submission must be in writing and must contain sufficient detail so that a determination can be made regarding meeting the Governments requirements. Any submission must be received in the contracting office by the COB 09/16/97. See Note 22 (0239)

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