National Cancer Institute, Research Contracts Branch, PSCS, 6120 Executive Blvd, Eps/room 638, Bethesda, MD 20892-7227

A -- SYNTHESIS OF 11 METABOLITES OF THALIDOMIDES SOL RFQ70191(nr) DUE 091897 POC Marsha Gorham, Purchasing Agent (301)402-4509 or Patricia Haun, Contracting Officer The National Cancer Institute (NCI) proposes to procure services involving the "Synthesis, Isolation, and Purification of 11 Metabolites of Thalidomide" from Dr. Frederick Luzzio, University of Louisville, Louisville, KY 40292. Background: The Clinical Pharmacokinetics Unit of the Division of Clinical Sciences, NCI, plans to evaluate the anti-tumor activity of 11 metabolites of thalidomide. This research requires the services of an organic chemist to develop new reactions to purify and isolate the 11 metabolites. The chemist contractor will have to consider stability issues in the reactions, and should use state-of-the-art technology such as mass spectrometry and NMR. Information on the 11 metabolites and other aspects of the requirement is available from the NCI purchasing agent listed in this notice. Requirements: The contractor shall: (1) develop an organic reaction to produce the 11 metabolites, (2) synthesize and purify these structures, (3) isolate and stabilize the structures, (4) assess purity with state of the art equipment, (5) provide supporting data to backup the synthesis and purify, (6) provide 100 mg of each of the compounds requested in a pure form, (7) write up a report of the experiments, (8) maintain an accurate and well organized lab book of data from this experiment, and (9) assist NCI in the preparation of a manuscript of this experiment. This notice is a combined synopsis/solicitation and NCI does not intend to issue a separate solicitation. Dr. Luzzio is the only source known to the NCI that can meet these requirements and this notice of intent is not a request for competitive proposals. However, if any interested party believes it can meet the above specification, it may submit a statement of capabilities. Information furnished must be in writing and must contain material in sufficient detail to allow NCI to determine if the party can perform the requirement. Capability statements must be received in the contracting office within 15 days after the publication date of this notice. See Note 22 (0241)

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