National Cancer Institute, Research Contracts Branch, PSCS, 6120 Executive Blvd, Eps/room 638, Bethesda, MD 20892-7227

A -- RESEARCH & DEVELOPMENT SOL NCI-RFQ-70188 DUE 091797 POC Cynthia Brown, Purchasing Agent, 301-402-4509, Patricia Haun, Contracting Officer This is a combined sole source synopsis/solicitation. The National Inst. Of Health, National Cancer Institutes Div. of Clinical Sciences/Medicine Branch intends to contract on a sole source basis with Annette Bicher, M.D., 3708 Woodbine Street, Chevy Chase, MD 20815. The Div. Of Clinical Sciences/MB/DTD/MOCS studies molecular causes of treatment failure in ovarian cancer. Ovarian cancer is the deadliest of gynecologic malignancies, with an estimated 25,000 new cases per year in the United States. The vast majority of patients present with advanced stage disease (70-80%); and in advances stage disease, only 10-15% of patients will experience long term disease free survival. Black Americans with advanced state ovarian cancer appear to respond less to standard chemotherapy than their non African American counterparts -- based on limited data from SWOG trials, reported by David Alberts, M.D. NCI's investigation of ovarian cancer requires skilled multi-disciplinary expertise from several specific disciplines. Specifically technical assistance shall be provided to: (1) Develop and monitor a gynecologic oncologic focus, for ongoing projects within the Medical Ovarian Cancer, Section; (2) Assist the section Head in the development and monitoring of molecular therapeutic approaches for this disease within the Section; (3) Develop and monitor collaborative efforts between the Section and gynecologic oncologist's in the Baltimore/Washington area; (4) Assist in the conduct of translational studies conducted within the Section in gynecologic malignancies; (5) Assist in the collection and collation of human tissue specimens relative to this disease; (6) Assist and monitor all data relative to ethnic issues that may be obtained; and (7) Assist in the collation of data and the writing of manuscripts, related to the responsibilities sited. Dr. Annette Bicher is uniquely qualified to perform the services specified herein. She is a board certified gynecologist who has published on the molecular pharmacology of platinum-DNA damage which is directly relevant to this project. Dr. Bicher has worked iin the Division of Clinical Sciences/Medicine Branch for a number of years. Most importantly, she has worked on this project and is throughly familiar with the protocol followed by NCI and all of its aspects and details. This is not a request for competitive proposals; no solicitation will be issued. However, vendors who believe they can meet the Government's requirements may submit their capability statements. Any submission must be in writing and must contain sufficient detail so that a determination can be made regarding meeting the Government's requirements. Any submission must be received in the contracting office by the COB 09/17/97. See Note 22. (0245)

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