National Cancer Institute, Research Contracts Branch, PSCS, 6120 Executive Blvd, Eps/room 638, Bethesda, MD 20892-7227

A -- RESEARCH & DEVELOPMENT SOL NCI-RFQ-70187 DUE 092397 POC Cynthia Brown, Purchasing Agent, 301-402-4509, Patricia Haun, Contract Officer This is a combined sole source synopsis/solicitation. The National Inst. of Health, National Cancer Institutes, Division of Epidemiology and Genetics Environmental Epidemiology Branch intend to contract on a sole source basis with the American Type culture Collection, 12301 Parklawn Drive, Rockville, Md. 20952. The purpose of the procurement is to extract DNA from 637 buffy coat samples for the testing of genetic polymorphisms. The study includes 736 samples (200 cases, 200 hospital controls with benign prostatic hyperplasia, and 336 population controls). It is essential that all buffy coat samples be extracted at the same laboratory and prepared exactly the same way to reduce laboratory variation. The Div. of Cancer Epidemiology & Genetics Environmental Epidemiology Branch is now prepared to extract DNA from all study samples to evaluate the role of androgen receptors, 5-alpha reductase, and vitamin D receptors in prostate cancer etiology. This contract is a continuation of previous contract whichhas been modified to take into account changes in the study design. This is not a request for competitive proposals; no solicitation will be issued. However, vendors who believe they can meet the Governments requirements may submit their capability statements. Any submission must be in writing and must contain sufficient detail so that a determinatino can be made regarding meeting the Government's requirements. Any submission must be received in the contracting office by the COB 9/23/97. See Note 22. (0246)

Loren Data Corp. http://www.ld.com (SYN# 0001 19970905\A-0001.SOL)