Contract Management Branch, National Institute of Neurological Disorders and Stroke, NIH, Federal Building, Room 901, 7550 Wisconsin Avenue, MSC 9190, Bethesda, Maryland 20892-9190

A -- TRANSGENIC RAT FOR STROKE RESEARCH DUE 110397 POC Raina Cervantes, Contracting Officer, 301-496-1813 E-MAIL: Laurie Leonard, ll44s@nih.gov. The NINDS intends to negotiate a sole source contract with Stanford University to continue development of a transgenic rat model for stroke research. The research objective includes design and construction of a transgenic rat that either lacks or overexpresses a specific gene that may be involved in the cellular injury or repair of brain cells within the central nervous system (CNS) following cerebral ischemia. The Principal Investigator at Stanford University (formerly at the University of California, San Francisco) has been successful in developing a founder rat colony that expresses the SOD-1 transgene. The original contract was awarded to UCSF in September 1995 based on the Principal Investigator's innovative approach submitted in response to a Broad Agency Announcement (BAA). Work under the UCSF contract will be terminated, and a new contract initiated with Stanford University to allow the Principal Investigator to complete the project requirements originally awarded. The next critical step in thedevelopment of the transgenic rat model will be empirical testing under experimental conditions. As a result of the Principal Investigator's move, Stanford University has become the only known source that can continue this important work at this point without delaying this research and duplicating costs to the Government. Authority: 41 U.S.C. 253 (c)(1), as set forth in FAR 6.302-1. See Numbered Note 22. (0262)

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