Contract Management Section, National Institute of Dental Research, NIH, Natcher Building, Room 4AN-44D, Bethesda, Maryland 20892-6402

A -- IMMUNOLOGIC FACTORS IN SALIVA AND BLOOD AS DETERMINANTS OF HIV-RELATED DISEASES SOL NIH-NIDR-4-97-9R DUE 111097 POC Marion Blevins, (301) 594-0652. The National Institute of Dental Research has a requirement of the development of methods and assays for selected immunological and viral characteristics in the saliva and serum of a cohort of HIV-positive persons. Approximately 2000 serum and 2000 saliva samples (to be furnished by the Government) will be tested for total IgG, IgM, and IgA; HIV-specific IgG, IgM, and IgA; nonspecific immune factors (lactoferrin, lysozyme and lactoperoxidase); levels of secretory leukocyte protease inhibitor; quantitative HIV virions; and infectivity of human peripheral blood mononuclear cells (PBMC). Special features of this project are the large number of samples and the need to develop procedures to apply to saliva as the matrix and conserve volume of specimen as much as possible. This is an announcement for an anticipated Request for Proposal (RFP). RFP No. NIH-NIDR-4-97-9R will be available approximately October 8, 1997, with a closing date tentatively set for November 10, 1997. Requests must be submitted in writing. Telephone and fax requests will not be accepted. All responsible sources my submit a proposal which will be considered by the NIDR. See Note 1. (0267)

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