National Institutes of Health, National Institute of Allergy and Infectious Diseases, Contract Management Branch, Solar Bldg., Room 3C07, 6003 Executive Blvd. MSC 7610, Bethesda, MD 20892-7610

A -- CLINICAL RESEARCH AND TRIAL PREPARATION SITES IN ENDEMIC AREAS SOL NIH-NIAID-DMID-98-19 DUE 012398 POC Carl Henn, Contracting Officer, (301) 496-0993; E-MAIL: ch24v@nih.gov The National Institute of Allergy and Infectious Diseases (NIAID) has a requirement to operate and maintain field sites in endemic areas for the study of malaria transmission and pathogenesis. Ongoing studies will provide information with respect to epidemiology, parasite populations, vector biology, immunity, and other factors influencing clinical presentation, as well as provide the opportunity for development and validation of case-definitions and field-appropriate diagnostics which will be valuable for clinical trials. These sites will also provide research reagents (e.g. parasite isolates, cells/sera from individuals with different forms of malaria) to the NIAID Malaria Research and Reference Reagent Repository. The contracts will include an option for expansion at individual sites to conduct safety, immunogenicity and efficacy testing of candidate vaccines as they become available. It is anticipated that three (3) to five (5) contracts will be awarded for a period of five (5) years, beginningapproximately September 27, 1998. RFP NIH-NIAID-DMID-98-19 will be available electronically on or about 10/21/97, and may be accessed through the NIH Gopher and/or the Internet by using the following electronic mail addresses and instructions: 1) NIAID/CMB Home Page (via the WWW): Use http://www.niaid.nih.gov/contract/ to access the NIAID/CMB Home Page. Once at the NIAID/CMB Home Page, click on the "RFPs" link and then click on "RFP-NIH-NIAID-DMID-98-19". 2) NIH Gopher: Point your Gopher client to GOPHER.NIH.GOV Port 70 (you should now be in the NIH Gopher). Select "Grant and Research Information"; select "R&D Request for Proposals (RFP)"; select "RFPs Available"; select "NIAID"; and select "RFP NIH-NIAID-DMID-98-19". Note: The direct URL (Uniform Resource Locator) address for this "R&D Request for Proposal (RFP) gopher directory is gopher://gopher.nih.gov:70/11/res/rd-rfp Please note that the RFP for this acquisition has been revised to include only the Work Statement, deliverable and reporting requirements, special requirements and mandatory qualification, if any, the Technical Evaluation Criteria, and proposal preparation instructions. All information required for the submission of an offer will be contained in the electronic RFP package. Following proposal submission and the initial review process, offerors comprising the competitive range will be requested to provide additional documentation to the Contracting Officer. Responses to this RFP will be due on 1/23/98. Any responsible offeror may submit a proposal which will be considered by the Government. This advertisement does not commit the Government to award a contract. No collect calls will be accepted. Point of Contact: Carl Henn, Contracting Officer Electronic Mail Address: ch24v@nih.gov Telephone: 301 496-0993 Fax: 301 480-5253 (0276)

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