DHHS, PHS, CDC, NIOSH, ALOSH, 1095 Willowdale Rd., Morgantown, WV 26505-2888

66 -- CONFOCAL MICROSCOPE SYSTEM SOL RP98-001 DUE 103097 POC Brenda Goodwin (304)285-5882/Contracting Officer, Rex S. Wolfe, Jr. (304) 285-5883 THIS IS A COMBINED SYNOPSIS/SOLICITATION FOR COMMERCIAL ITEMS PREPARED IN ACCORDANCE WITH THE FORMAT IN SUBPART 12.6, AS SUPPLEMENTED WITH ADDITIONAL INFORMATION INCLUDED IN THIS NOTICE. THIS ANNOUNCEMENT CONSTITUTES THE ONLY SOLICITATION; BIDS ARE BEING REQUESTED AND A WRITTEN SOLICITATION WILL NOT BE ISSUED. This solicitation is issued as Request for Proposal No. 97-022. This procurement is being issued unrestricted. The Standard Industrial Classification is 3826 with a size standard of 500 employees. This solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular 90-46. Furnish and install at the National Institute for Occupational Safety and Health (NIOSH), 1095 Wilowdale Road, Morgantown, WV one each of a confocal laser scanning microscope system in accordance with the specifications below. Offerors shall identify all contract line items (CLINS), accessories and/or options required to meet the specification and provide individual pricing.SPECIFICATIONS: This project will involve treatment of cell cultures with powerful environmental carcinogens and determination of gene expression and genetic damage. Normal human bronchial and mammary epithelial cells provide important model systems for the investigation of mechanisms of human chemical carcinogenesis. This project seeks to determine the principal genetic and epigenetic changes wrought by chemical carcinogens found in the work-place. Markers of early damage include the formation of chemical-adducts in the genetic material (DNA). Cutting-edge technology to assess the impact of environmental and occupational exposures on the expression of scores of genes simultaneously will be used. At one level these studies will assist in our understanding of mechanisms of human chemical carcinogenesis; at another, more advanced, level these studies have the potential to lead to the development of markers of exposure; and thereby assist in development of strategies for early detection and intervention. Required is an instrument with air cooled argon laser with point scanning capability. The instrument must have variable laser attenuation to provide 0, 6, 20, 50 and 100% transmission over a confocal pinhole range of 80 -- 300micrometers (incremental at 80, 100, 150, 200 and 300microns). The instrument should have a variable field and subscan modes with z-axis minimum step 0.1micron. The unit should be operational in six independent scan modes (XY, XYZ, XZ, XYT, XT, XYZT). The laser should be direct couple, 1024 x 1024 pixel resolution and 12 bit depth single scan acquisition -- NOT in repeated accumulation scan mode. The unit should have high image sensitivity and lateral resolution. The instrument must have dual photomultiplier tubes for simultaneous acquisition of 2 images, and simultaneous acquisition of Differential Interference Contrast (DIC). The unit should have high bit-depth image resolution, transmitted light acquisition, 2D and 3D applications software and be adaptable to both inverted and uprightmicroscopes. Offer shall include installation, an operation manual, training and a technical support program. The confocal system should be compatible with existing Olympus IX70 microscope equipment. The Government desires delivery of all items within thirty days after award of contract. Evaluation Factors: Offers will be evaluated for technical compliance with the stated specification. OFFERS SHALL BE PROPOSED BASED ON F.O.B. DESTINATION (MORGANTOWN, WEST VIRGINIA) AND THE REQUIREMENTS AT FAR 52.214.21 "DESCRIPTIVE LITERATURE" APPLY. INFORMATION PROVIDED WITH YOUR OFFER MUST DEMONSTRATE THE UNIT'S ABILITY TO MEET THE SPECIFICATION OR YOUR OFFER MAY BE REJECTED. The following FAR provisions apply to this solicitation: FAR 52.212-1, Instructions to Offerors -- Commercial Items; 52.212-4, Contract Terms and Conditions -- Commercial Items and 52.212-5 Contract Terms and Conditions Required to Implement Statutes or Executive Orders -- Commercial Items. Additionally, the following FAR clauses cited in Clause 52.212-5 are also applicable to this acquisition as follows: FAR 52.222-3 "Convict Labor (E.O. 11755)", 52.233-3 "Protest After Award (31 U.,S.C. 3553 and 40 U.S.C. 759)", 52.203-6 "Restrictions on Subcontractor Sales to the Government, With Alternate I"; 52.203-10 "Price or Fee Adjustment for Illegal or Improper Activity", 52.219-8 "Utilization of Small Business Concerns and Small Disadvantaged Concerns; 52.222.26 "Equal Opportunity"; 52.222-35 "Affirmative Action for Special Disabled and Vietnam Era Veterans"; 52.222-36 "Affirmative Action for Handicapped Workers"; 52.222-37 "Employment Reports on Special Disabled Veterans and Veterans of Vietnam Era"; 52.225-3 "Buy American Act -- Supplies"; 52.225-18 "European Community Sanctions for End Products." No other solicitation documents will be issued. Offers are due by October 30, 1997, 3:00 p.m. local prevailing time. Submit the following to DHHS, PHS, CDC, NIOSH, ALOSH, Attn: Brenda Goodwin, 1095 Willowdale Road, Morgantown, WV 26505: (1) original and three copies of a completed SF 1449, signed by an individual authorized to bind the organization; (2) Schedule of Offered Supplies/Services containing pricing of Contract Line Items (CLINs) required to meet specification; (3) completed Representations and Certifications -- Commercial Items, FAR 52.212-3; (4) for evaluation purposes: descriptive literature, tables, etc. which demonstrate the proposed instrument's compliance with all specifications; (5) published price lists (if available) and (6) acknowledgment of solicitation amendments, if any. Facsimile Bids are not authorized. Offers that fail to furnish the required information, or reject the terms and conditions of the solicitation may be excluded from consideration. Award of a one firm fixed-price contract is anticipated. This announcement is issued subject to availability of funds. Forms required for submission of an offer can be obtained from Brenda Goodwin at (304)285-5882 or by fax at (304) 285-6083. All responsible sources may submit a response, which shall be considered by the Agency. (0280)

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