National Cancer Institute, Research Contracts Branch, PSCS, 6120 Executive Blvd, Eps/room 638, Bethesda, MD 20892-7227

A -- RESEARCH & DEVELOPMENT SOL RFQ-NCI-80011 DUE 111097 POC Cynthia Brown, Purchasing Agent, (301) 402-4509, Patricia Haun, Contracting Officer The National Institutes of Health, National Cancer Institute, Division of Clinical Sciences intends to issue a Sole Source purchase order to Louisiana State University Medical Center, Stanley Scott Cancer Center, 1542 Tulane Ave., Rm. 441, New Orleans, La. 70112 for the Evaluation of alterations in signal Transduction Molecules in patients with Breast Cancer. The Immunotherapy Laboratory at Louisiana State University Medical Center has developed novel approaches to evaluate the immune system by measuring alterations in signal transduction proteins and in nuclear transcription factors. The process of T cells simulation and activiation is initiated by the coordinated binding of antigen to the T cell receptor (TCR) and a costimulatory signals to the corresponding receptors. This process is altered in patients with different types of cancer, however, little is known in patients with breast cancer. Based on the novel approach and current results of this testing, as well as ongoing collaborations between this laboratory and the Division of Clinical Sciences, Louisiana State University Medical Center is the only source who can fulfill this need. It is essential to the Division of Clinical Science that the process of T cell simulation and activiation be charted for breast cancer patients in order to gaither information regarding immune dysfunction and immune response inhibitors as a result of breast cancer at different stages of progression. This is not a request for quotes vendors who believe they can meet the government requirements may submit their qualifications. The submission must be in writing and must contain sufficient detail so that a determination can be made regarding meeting the governments requirements. The submission must be received by the COB November 10, 1997. No collect calls will be accepted. (0294)

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