U.S. Environmental Protection Agency, 26 W. Martin Luther King Dr., Cincinnati, OH 45268

A -- PILOT STUDIES OF THE EFFECTS OF BERKSON-TYPE EXPOSURE MEASUREMENT ERRORS ON REGRESSION MODELS OF MORTALITY AND MORBIDITY SOL RFQ-OH-98-00018 DUE 110697 POC Marie Nichols (513) 366-2054 E-MAIL: U.S. EPA -- Cincinnati Contracts Management Division, nichols.marie@epamail.epa.gov. The United States Environmental Protection Agency, Office of Research and Development, National Center for Environmental Assessment, requires technical and scientific support in the creation and analysis of a statistical database for studies of health effects in air pollution in Philadelphia during the 1991-1994 period. The proposed contract action will require the contractor to have access to or acquire three data bases which shall be integrated as part of the study: (1) daily data on airborne thoracic particles (PM10) from two or more monitoring sites, and other air pollution data from these sites; (2) daily data on one or more spatially dis-aggregated health endpoints that will allow some measure of assignment of health endpoints to spatially dis-aggregated air pollution data, using methods to be developed by the contractor; (3) meteorological data appropriate to characterize weather and climate effects on the health endpoints. The Contractor shall perform statistical analyses appropriate to formulation of a computer simulation model that will allow assessment of the role of spatial heterogeneity in a regional spatially disaggregated daily time series analysis of the health endpoint. This project is a pilot study to evaluate the feasibility of developing spatially disaggregate epidemiology models in urban areas with multiple particulate matter monitoring stations. The SIC code is 8742. The Government anticipates the award of a fixed-price contract for the project. The EPA intends to issue a request for a written quotation (RFQ) which will include technical evaluation criteria. The anticipated release date for the RFQ is November 6, 1997. All responsible sources may issue a written quotation which will be considered by the Agency. Requests for the RFQ must be in writing. NO TELEPHONE REQUESTS WILL BE ACCEPTED. E-mail or faxed requests are acceptable. The fax number is (513) 366-2107. The mailing address is U.S. EPA, Contracts Management Division, 26 W. Martin Luther King Drive, Cincinnati, OH 45268, Attn: Marie Nichols. (0295)

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