National Cancer Institute, Research Contracts Branch, Cancer Etiology Contracts Section, Executive Plaza South, Rm. 620, 6120 Executive Blvd., MSC 7224, Bethesda, MD 20892-7224

B -- CELLULAR AND MOLECULAR STUDIES OF HUMAN HEPATOCARCINOGENESIS IN CHINA SOL RFP N02-BC-81-21-21 DUE 030998 POC Barbara A. Shadrick, Contracting Officer, phone (301)435-3787, fax (301)480-0241 E-MAIL: Barbara A. Shadrick, bs92y@nih.gov. The Laboratory of Experimental Carcinogenesis (LEC), Division of Basic Sciences (DBS), National Cancer Institute (NCI), National Institutes of Health (NIH), plans to negotiate a three-year follow-on option contract with the Cancer Institute, Chinese Academy of Medical Sciences, Beijing 100021, Peoples Republic of China, to screen high risk human hepatocellular carcinoma in individuals in two Chinese townships. The main objective of this study is to follow the previous study to continue to test the hypothesis that exposure to aflatoxin B1 is associated with increased allelic losses during the development of human hepatocellular carcinoma and examine the association between serum alpha-fetoprotein levels and the expansion of the stem cell compartment in the lever. The statutory authority for this non-competitive acquisition is 41 U.S.C. 253(c)(1), as set forth in FAR 6.302-1(b)(1). See Numbered Note 22. No collect calls will be accepted. (0338)

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