DHHS/National Institute on Alcohol Abuse and Alcoholism, Contracts Management Branch, Wilco Building, Suite 504, 6000 Executive Boulevard, MSC 7003, Bethesda, Maryland 20892-7003

A -- THE ROLE OF NUTRITION IN THE ESSENTIAL FATTY ACID STATUS OF PREGNANT WOMEN WHOSE FETUSES ARE AT RISK FOR ALCOHOL-RELATED BIRTH DEFECTS. SOL AA 98-07 DUE 022498 POC Matthew L. Packard, Contract Specialist (301)443-1191 WEB: NIAAA Home Page, http://www.niaaa.nih.gov. E-MAIL: Sandra Reichard, sreichar@willco.niaaa.nih.gov. The National Institute on Alcohol Abuse and Alcoholism (NIAAA) intends to negotiate a one year contract (with an Option year) with Wayne State University in Detroit, MI entitled "The Role of Nutrition in the Essential Fatty Acid Status of Pregnant Women whose Fetuses are at Risk for Alcohol-Related Birth Defects." The purpose of this contract is to assist the Laboratory of Membrane Biochemistry and Biophysics, NIAAA in examining the effect of alcohol use during pregnancy on fatty acid composition and metabolism in the neonate. The specific aims include the study of the effect of alcohol abuse during pregnancy on normal essential fatty acid accumulation in the mother and neonate, and investigation of the mechanisms underlying this effect, i.e., determining whether changes in the levels of essential fatty acids are due to alterations in diets, decreased production, and/or increased catabolism. Authority: 41 U.S.C. 253(c)(1), as set forth in FAR 6.302-1; Wayne State University is the only responsible source having an existing clinical research program that is currently studying a suitable large population composed primarily of pregnant African-American women. Inquiries must be sent in writing; telephone inquiries are unacceptable. All responsible sources may submit a proposal which, if timely, will be considered by the Government. See Numbered Notes 22 and 26 in the Commerce Business Daily. (0008)

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