National Cancer Institute, Research Contracts Branch, PSAS, 6120 Executive Blvd, EPS/Room 638, Bethesda, MD 20892-7227

R -- STATISTICAL CONSULTING IN CANCER PREVENTION SOL RFQ-80073-NV DUE 022398 POC Debbie Moore, Purchasing Agent 301/402-4509, Trish Haun, Contracting Officer 301/402-4509 The National Cancer Institute NCI intends to issue a sole source RFQ to Mr. Laurence Freedman to provide expert statistical consulting in cancer prevention for the Division of Cancer Prevention, Office of the Director on projects associated with (i) Middle East Cancer Consortium (MECC) Joint Cancer Registration Project; (ii) Polyp Prevention Trial (PPT); (iii) Breast Cancer Prevention Trial. For the MECC it is necessary for the individual/organization to have a solid working relationship with the participants including a knowledge of the Middle East region and its politics, to handle sensitive issues, involving partners of Middle East countries. For analysis work for the PPT results require an individual/organization with the understanding of the methodology of the dietary intervention clinical trials, colon cancer epidemiology, measurement error methods, as well as a close knowledge of the manner in which the PPT was designed and its data collected. The monitoring of the BCPT is an extremely complex problem owing to the multiple diseases that are potentially affected by tamoxifen, some in a beneficial and some in a harmful ways. The proposed contractor has developed a novel statistical method for doing this which has been adopted by the members of the Endpoint Review Safety Monitoring Advisory Committee (ERSMAC). This study requires an individual/organization with expertise in the validation of surrogate endpoints in cancer research. Mr. Freedman, a former NCI employee, has years experience in the above mentioned studies an in depth knowledge, valuable links and networks all over which provide him with an expertise and knowledge of this unique combination of three highly visible projects. This is not a solicitation for competitive proposals. However, individuals/organizations who believe they meet all of these requirements, may submit a proposal with all evaluative materials to make an award to Debbie Moore, 6120 Executive Blvd., Rockville, MD 20892-7227 no later than February 23, 1998 at 2:00 PM EST. No collect calls will be accepted. See Note 1 and 22. (0034)

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