Loren Data Corp.

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COMMERCE BUSINESS DAILY ISSUE OF MARCH 3,1998 PSA#2043

National Institutes of Environmental Health Sciences, Research Contracts Branch, DERT, P.O. Box 12874, Building 4401, Research Commons, 79 T.W. Alexander Drive, Research Triangle Park, NC 27709

A -- COORDINATING CENTER FOR THE AFRICAN-AMERICAN DIABETES MELLITUS STUDY. SOL NIH-HG-98-24 POC Velvet M. Torain, Contract Specialist, 919/541-0440/Phillip D. Jones, Contracting Officer 919/541/0426 WEB: None, None. E-MAIL: None, None. The National Institute of Environmental Health Sciences intends to negotiate a contract with Howard University College of Medicine, Washington D.C. to study the genetic susceptibility to non-insulin dependent diabetes millitus in African-Americans. This study will build on results of a one-year pilot study conducted by Howard University scientists in collaboration with scientists at the National Human Genome Research Institute. The objectives are to continue to oversee and direct recruitment of appropriate affected sib pairs of African decent for collaborative genomic research through the recruitment centers in Nigeria and Ghana; expand the already standardized protocols for collection of genetic, clinical and epidemiological data on the study population; and refine core facilities already established at Howard University for the isolation; characterization and storage of cells and DNA for genomic and biological studies. The work will be conducted through the establishment of a coordinating center at Howard University. The Center will receive all clinical epidemiological, biological data associated with the contract ensuring the confidentiality of all records and samples received and provide assurances the samples will not be used for other purposes. The Center will prepare DNA, process samples for genotyping and forward to NHGRI for analysis; and provide quality control of samples and data received for recruitment centers. The Center shall also direct and oversee the collaborative recruitment centers which should together be able to identify a total of 400 affected sib pairs. The contract will be for three years with a planned award date on or before September 1, 1998. It is anticipated that this project will require approximately 16,848 man hours over the three years. Authority: 41USC 253(c)(1), as set forth in FAR6.302-1 -- Only One Responsible Source. Howard University is uniquely qualified to perform this project. Howard University has conducted the pilot study for this project and therefore has anestablished laboratory and data base. Any other interested sources desiring consideration for this requirement must fully identify their interests and capabilities to the Contracting Officer listed above. See Numbered Notes 22 and 26. (0058)

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