National Institute of Environmental Health Sciences, Acquisitions Management Branch, 79 T.W. Alexander Drive, Building 4401 Research Commons, P.O. Box 12874, Research Triangle Park, NC 27709

B -- DEVELOPMENT OF LIST OF KNOWN GENES THAT ARE INVOLVED IN RESPONSES TO ENVIRONMENTAL CHEMICALS AND MAY INFLUENCE SUSCEPTIBILITY TO HUMAN DISEASE SOL 273-98-P-0007 DUE 043098 POC Contact Diane L. Crawford, Contracting Officer, (919)541-7685; FAX (919)541-2712 WEB: none, none. E-MAIL: none, none. The Government requires services for research and development of a WEB site with a list of known genes that are involved in responses to environmental chemicals that may influence susceptibility to human disease. The contractor will be required to search all known macromolecular information resources and based on literature analysis, determine all pertinent annotation, biological and biochemical information which would identify the gene as environmentally relevant, including but not limited to identification of the translation product, and its function in metabolism, as well as known polymorphic variations, modes of regulation of expression, phenotypic variation of known polymorphisms and tissue specificity. Offers will be accepted from both large and small business under full and open competition. (0068)

Loren Data Corp. http://www.ld.com (SYN# 0014 19980311\B-0003.SOL)