National Institutes of Health, National Institute of Allergy and Infectious Diseases, Contract Management Branch, Solar Bldg., Room 3C07, 6003 Executive Blvd. MSC 7610, Bethesda, MD 20892-7610

A -- CENTRALIZED IMMUNOLOGY LABORATORY SUPPORT SOL NO1-AI-65305 POC Lawrence M. Butler, Contracting Officer, (301) 496-0192 The National Institute of Allergy and Infectious Diseases (NIAID) intends to negotiate a modification to its 7 year cost-reimbursement contract with Duke University Medical Center NO1-AI-65305, as a sole source under authority of 41 USC 253 (c) (1) and FAR 6.302-1. The contract currently provides standard, centralized immunology laboratory support for the evaluation of immunization-induced systemic humoral and cellular responses of volunteers enrolled in NIAID-sponsored Phase I and II Clinical Trials of experimental AIDS vaccines. The negotiated modification will increase the number of assessments of candidate AIDS vaccine-induced anti-HIV-1 env, gag, pol and nef CD8+ Cytotoxic T Lymphocyte (CTL) activity currently being performed under the contract. Continued access to and support for these CTL assessments is necessary to avoid a disruption in the evaluation of vaccine immunogenicity in NIAID-sponsored Phase I and II Clinical Trials of experimental AIDS vaccines. See numbered Note 22. No collect callswill be accepted. (0071)

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