U.S. Environmental Protection Agency, National Center for Environmental Assessment (MS117), 26 West Martin Luther King Drive, Cincinnati, OH 45268

A -- RESEARCH ON THE TOXICOKINETICS OF INTERACTION EFFECTS OF MULTIPLE EXPOSURES TO CLASSES OF PESTICIDES MIXTURES AND AGE-RELATED RISKS SOL NCEA-CIN-03 DUE 042098 POC Donna Tucker, FAX No. (513) 569-7475 E-MAIL: Click here to e-mail EPA Contact, tucker.donna@epamail.epa.gov. Requirements-The United States Environmental Protection Agency, National Center for Environmental Assessment -- Cincinnati Office (NCEA-CIN), seeks pre-proposals to conduct toxicological research related to the development of human health risk assessment methodologies for both cancer and non-cancer effects from environmental exposure to mixtures of pesticides. Areas of interest include the elucidation of mode of action; toxicokinetics of pesticides mixtures interactions; and associated age-related risks. The pesticides of interest include selected classes of organophosphate, organochlorine, carbamate, and pyrethrin compounds. The research activities will focus on the interactions of the pesticides mixtures and potential additive, synergistic, or antagonistic adverse health effects. The intent is to develop a three year cooperative agreement on the announced research areas of interest with the primary purpose of designing the risk assessment methodology. NCEA-CIN scientists will collaborate inthe research by providing experimental design and risk assessment methodology information, and by the authorship of research publications. Pre-proposals must not exceed 10 pages and will be thoroughly reviewed and evaluated by a technical evaluation panel of scientists. Successful pre-proposals will be invited to submit a competitive cooperative agreement application, including a full and detailed project proposal for funding consideration. Depending on funding availability, the awards are estimated to range from $50,000 to $300,000 total over 3 years. Interested applicants must be eligible to receive Federal Assistance under the Federal Insecticide, Fungicide and Rodenticide Act (FIFRA), Section 20(a). ONLY NONPROFIT RESEARCH INSTITUTIONS OF HIGHER EDUCATION ELIGIBLE TO RECEIVE FEDERAL ASSISTANCE UNDER THIS ACT SHOULD SUBMIT A REQUEST FOR PRE-PROPOSALS. Proposals from other Federal Agencies are not solicited and will not be accepted. Interested parties may obtain a copy of Solicitation #NCEA-CIN-03 by contacting Donna Tucker, USEPA, National Center for Environmental Assessment -- Cincinnati Office, MS-117, 26 W. ML King Dr., Cincinnati, Ohio 45268; FAX: 513-569-7475 postmarked no later than April 20, 1998. ORAL REQUESTS WILL NOT BE ACCEPTED. (0076)

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