DHHS/FDA/NCTR, Contracts Branch, HFT 322, 3900 NCTR Road, Jefferson, AR 72079-9502

66 -- TRIPLE QUADRUPOLE LC/MS/MS SYSTEM FOR ANALYSIS OF TOXICOLOGICALLY SIGNIFICANT MOLECULES SOL 222-98-2008(P) POC Laura F. Bates, 870-543-7068/Priscella Sullivan 870-543-7271 The description is changed to include the full text as follows: The National Center for Toxicological Research intends to conduct negotiations with and award a contract to Micromass, Inc., Beverly, MA on a basis of other than full and open competition for the purchase of a compact benchtop triple quadrupole mass spectrometer (MS/MS) designed to accept liquid chromatography (LC) interfaces for the study of a wide range of small molecules (e.g., drugs and metabolites with molecular weight <1,000 amu) as well as biopolymers (proteins and nucleic acids with molecular weights greater than 100,000 amu). The interfaces must provide for analysis of samples containing involatile buffers and salts and system operation must be compatible with the presence of involatile buffers in LC mobile phases. The system must come equipped with a novel double orthogonal API source, Z-Spray which must not use a high heat/low volume environment and must accommodate flow rates from 1-1000 ul/min. Mass range must be 4,000 amu for both analyzers. The system must have a Microsoft Windows NT operating/data processing system that is fully multi-tasking and be capable of sophisticated data manipulations and quantification procedures performed on a single PC in order to be compatible with existing auxiliary hardware/software. System must have a photomultiplier detector with high energy conversion dynode to ensure high sensitivity and long lifetime (10 years minimum). Micromass has the knowledge and expertise to provide the particular, compatible equipment. "See Note 22" (0093)

Loren Data Corp. http://www.ld.com (SYN# 0382 19980407\66-0007.SOL)