National Institutes of Environmental Health Sciences, Research Contracts Branch, DERT, P.O. Box 12874, Building 4401, Research Commons, 79 T.W. Alexander Drive, Research Triangle Park, NC 27709

A -- STUDIES TO EVALUATE THE TOXICOLOGIC AND CARCINOGENIC POTENTIAL OF CHEMICALS BY ORAL AND DERMAL EXPOSURE SOL NIH-ES-98-26 DUE 050198 POC Saundra J. Walsh, Contract Specialist 919/541-0419, Dr. William R. Johnston, Contracting Officer 919/541-0419 WEB: NONE, NONE. E-MAIL: NONE, NONE. The purpose of this contract is to conduct studies to evaluate the toxic and carcinogenic potential of selected chemicals by oral and dermal exposure. The chemicals to be studied are Diisopropylcarbodiimide (DIC), Methylene Blue, Bromocloroacetic Acid, Dibromoacetonitrile Acid (DBAN), Dichloroacetic Acid and Bromodichloroacetic Acid. Multiple studies are to be conducted concurrently. The base contract award includes the conduct of Phase 1- prestart activities for all chemicals. During Phase 1, the contractor shall perform those work activities associated with the determination of bulk chemical purity and identity, and validation of dose formulation/analysis methods, any health and safety concerns that must be addressed before study start. It is anticipated that the contract shall also contain options for the conduct of other Phase 2 -- 4 studies as follows: DIC (Task 1) and Methylene Blue (Task 2), Phase 2, 2-year studies (which consists of treatment, observations, other tests, as necessary,and necropsy and pathology);Bromochloroacetic acid (Task 3) includes a Phase 2, 14-Day Study and Phase 3, 90-Day Study, Phase 4 -- 2-Year Study of Male Rats and Female Mice, and optional Phase 4 -- 2-Year Study Female Rats and Male Mice, Dibromoacetronitrile (Task 4) Phase 2 -- 14-day Study, Phase 3 -- 90-Day Study and Phase 4 -- 2-Year Study; Dichloroacetic acid (Task 5) Phase 2 -- 90-Day Study, an Optional Cell Proliferation Study, and Phase 3 -- 2-Year Study; Bromodichloroacetic Acid (Task 6) Phase 2 -- 14-Day Study, Phase 3 -- 90-Day Study, Phase 4 -- 2-Year Study (male rats and female mice), and optional 2-Year Study (female rats and male mice). One completion form cost reimbursement type contract is anticipated. The performance period for the base contract is expected to be seven and 1/2 months. Should the optional studies be exercised, the period shall be extended to June 30, 2003. For estimating purposes the Government anticipates an approximate level-of-effort of 167,685 hours for the contract including all options. Offerors must have a working laboratory in place at the date of proposal submission. Only minor renovation in order to meet the specifications should be necessary prior to contract award. In addition, the Principal Investigator, Toxicologist, Chemist, Health and Safety Officer and Quality Assurance Unit Officer shall be employees of the contract laboratory. Consultants and subcontractors may not be proposed for these discipline areas. The expected release date of the RFP is May 1, 1998 with proposals due June 30, 1998. Interested organizations should request either a streamlined or full RFP package. If no selection is made, a streamlined version of the RFP will be provided, which includes only the Statement of Work, deliverable and reporting requirements, special requirements and mandatory qualifications, if any, and technical evaluation criteria. After examination of these documents, any organization interested in responding to this RFP must request the entire RFP in writing or by telephone (919) 542-0419 or by FAX request (919) 541-2712. This is an unrestricted competition. All responsible sources may submit a proposal which shall be considered by the agency. SIC Code 8731. (0104)

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