Contracts Management Section, National Institute of Dental Research, NIH, Natcher Building, Room 4AN-44D, 45 Center, Drive MSC 6402, Bethesda, Maryland 20892-6402

A -- GENOMIC SEQUENCING OF STREPTOCOCCUS GORDONII SOL RFP NIH-NIDR-4-98-1 DUE 061598 POC Marion L. Blevins, 301 594-0652 The National Institute of Dental Research, NIH, intends to negotiate on a sole-source basis with The Institute for Genomic Research (TIGR) for the sequencing of the entire genome of Streptococcus gordonii. The strain of S. gordonii to be sequenced participates in lactose-sensitive co-aggregations with Actinomyces naeslundii and is transformable. The objectives of the project are to complete shotgun sequencing of the genome of this strain already begun during a previous project at TIGR, to close the sequence, check the accuracy of the data, release the data on an Internet Home Page, and to make the DNA fragment clones available to the research community. TIGR is uniquely qualified to complete this project within two years and has already completed library construction and sequencing of approximately one half of the genome. The authority is 41 USC 253(c)(1), as set forth in FAR 6.302-1. See Note 22.***** (0119)

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