Centers for Disease Control and Prevention (CDC), Procurement & Grants Office, Program Acquisition Branch, 255 East Paces Ferry Rd, NE, Rm 500, Atlanta, GA 30305

B -- STATISTICAL DATA ANALYSIS SOL 98S188(Q) DUE 052198 POC Anne Wright, Purchasing Agent, (404) 842-6771 The Centers for Disease Control and Prevention intends to negotiate with and award a contract to The University of Washington School of Medicine. The award will be made on a sole source basis for professional services to conduct a statistical analysis of HIV genetic sequence data from existing CDC data collection. From a previous study, genetic sequencing on a well characterized collection of specimens was collected from HIV infected individuals in public health clinics and blood centers in the United States. To date, sequencing has been done on 100 specimens. The requirement necessitates a vendor who shall perform in-depth analysis of data from the 100 sequenced specimens. In the absence of cohort information the vendor shall: Develop summary and descriptive statistics to provide a complete picture of nucleotide variability; Predict the putative cohort structure using different methods; Provide estimates on the growth of the epidemic using coalescent methods. In the presence of cohort information the vendor shall: Develop summary and descriptive statistics in order to provide a complete picture of nucleotide variability between cohorts; Analyze congruence between group structure and predicted group structure; Conduct coalescent analysis to estimate the rate of transmission between cohorts and the migration rates. Other analysis require identification of putative recombinants using existing and novel methods and identification of the rate of recombination using coalescent methods. The period of performance for the proposed contract is not to exceed six months from date of award. Other than full and open competition is authorized pursuant to 41 U.S.C. (253 (c) (1). Minimum qualifications of prospective offerors shall be: Previous participant in laboratory studies and analysis of CDC's HIV specimens; Access to specimen data and the ability to site specific data necessary to answer research questions; Advanced degrees in clinical, laboratory and/or social sciences coupled with previous experience in conducting similar analysis. Due to the urgency of this requirement, prospective offerors will have 15 days from the date of synopsis to submit capability statements which shall define ability to provide services identified herein. Capability statements shall be mailed or faxed to Anne A. Wright at address listed in (7) seven, above. Such qualifications will be used solely for the purpose of determining whether to conduct a competitive procurement. No solicitation exist and request for such document will be considered non-responsive. Telephone responses will not be accepted. (0128)

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