National Institutes of Environmental Health Sciences, Research Contracts Branch, DERT, P.O. Box 12874, Building 4401, Research Commons, 79 T.W. Alexander Drive, Research Triangle Park, NC 27709

A -- STUDIES TO EVALUATE THE TOXIC AND CARCINOGENIC POTENTIAL OF SELECTED CHEMICALS IN LABORATORY ANIMALS VIA INHALATION SOL NIH-ES-98-27 DUE 081798 POC Contract Specialist, Jacqueline A. Osgood, 919-541-7596 WEB: None, None. E-MAIL: None, None. The purpose of this contract is to evaluate the toxic and carcinogenic potential of selected chemicals of interest via inhalation. This project includes 14-day, 90-day, and two year studies of Methyl Isobutyl Ketone, Alpha-Methylstyrene, Cumene, and Propargyl Alcohol. The base contract award shall consist of those work activities associated with identity and purity determination of bulk chemical, development of generation and monitoring methods, health and safety concerns that must be addressed before start, and conduct of the Phase 1 for Tasks 1 (Methyl Isobutyl Ketone), Task 2 (Alpha-Methylstyrene), Task 3 (Cumene) and Task 4 (Propargyl Alcohol. The Government may, pending the availability of funds exercise options for: 90-day study of Methyl Isobutyl Ketone, a two-year study of Methyl Isobutyl Ketone (Task I); 90-day study of Alpha-Mehtylstyrene, a two-year study of Alpha-Mehtylstyrene (Task II) 90- day study of Cumene, a two-year study of Cumene (Task III), and 90-day study of Propargyl Alcohol, a two year study of Propargyl Alcohol (Task IV). These studies shall be conducted according to the Specifications for the Conduct of Studies to Evaluate the Toxicologic and Carcinogenic Potential of Selected Chemicals in Laboratory Animals Via Inhalation for the National Toxicology Program (NTP) dated April 1998. Award of one cost-reimbursement, completion contract on May 21, 1999 on an open competition basis is contemplated as a result of this solicitation. The estimated level of effort is 12,650 labor hours for the base contract and 148,261 labor hours for all options. The estimated period of performance is approximately six months months for the base contract and four year eleven months if all options are exercised. Interested organizations should request either a streamlined or full RFP package by written, telephonic ((919) 541-7596), or telefax request ((919-541-2712). If no selection is made, a streamlined version of the RFP will be provided, which will include only the Statement of Work, deliverables andreporting requirements, any special requirements, mandatory qualifications, and technical evaluation criteria. After examination of the streamlined RFP, any organization interested in responding to this RFP must request the full RFP package. A copy of the streamlined and full RFP (with statement of Work only) will be available after the release date on the Internet at http://www.niehs.nih.gov/omcpmb/external/rfp.htm. Those individuals who wish to access the on-line version should follow the instructions provided in the on-line solicitation package. All responsible sources may submit a proposal which shall be considered by the Agency. Expected release date of the RFP is August 17, 1998 with proposals due October 9, 1998.***** Posted 06/30/98 (0181)

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