National Institute on Drug Abuse, Division of Intramural Research, PO Box 5180, Baltimore, MD 21224-0180

R -- PROFESSIONAL SERVICE FOR ANALYTICAL CHEMIST SOL NIDA-98-JCA002 DUE 082198 POC Janes C. Amend -- Tel.-410-550-1637; Fax.-410-550-3146 The Integrative Neuroscience Unit of the NIDA IRP is seeking a Masters or Ph.D. level Analytical Chemist with expertise in HPLC/EC, HPLC/fluorescence, microdialysis (conventional and quantitative) and rotating disk electrode voltametry. The individual will be responsible for: 1) development of HPLC procedures for the analysis of catecholamine and excitatory amino acid release from discrete regions of the CNS. 2) quantification of fentamolar-nanomolar concentrations of catecholamines/amino acids from CNS dialysate samples. 3) the conduct and analysis of conventional and quantitiative in vivo microdialysis experiments in the rodent and non-human primate. 4) design and conduct of kinetic studies of dopamine and serotonin transporter function using rotating disk electrode voltametry. 5) assisting in the write-up and presentation of data. Familiarity with laboratory animals is essential. The individual will be part of a team assessing the mechanisms in the brain by which cocaine and methamphetamine produce long-term alterations in brain function. Term for Completion: September 1, 1998 thru September 6, 1999. Direct questions or inquiries referencing the rfq no. by return FAX (410-550-3146). Proposals shall be received by the NIDA/IRP, 5500 Nathan Shock Drive, Baltimore, MD #21224. Posted 07/07/98. (0188)

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