DHHS/PHS/FDA/Office Of Facilities, Acquisition, And Central Services, Division of Contracts and Program Management, HFA-512(COB), 5600 Fishers Lane, Rockville, MD 20857

66 -- MASS SPECTROMETER SOL 221-98-7150 DUE 090198 POC Trudy Dartouzos, Contract Specialist, ph: 301-827-7165 The FDA, Center for Veterinary Medicine requires a triple stage mass spectrometer not to include refurbished parts or elements. Benchtop (can be placed on tabletop), transmission type analyzer, metallic alloy quadrupole mass analyzer, three sectors consisting of quadrupole mass filter, collision cell equipment with linear acceleration, quadrupole mass filter, enables multiple mass spectral acquisition techniques, MS, MS/MS production scanning, multiple reaction monitoring, constant neutral loss, parent ion scanning, high pressure RF-only ion guide prior to first sector, rapid scanning [2400 amu/sec), selected ion monitoring, collision induced dissociation [CID/MS/MS], alternate positive/ negative ion scanning, alternate MS and CID/MS scanning, mass range 5-1800 amu, resolution MS/MS, all singly-charged fragment ions in the product ion spectrum of the doubly-charged molecular ion of Renin Substrate [m/z 880] will show unit resolution without having to adjust Q3 rod offset of resolution with mass demonstrated by infusing a 10 picomole/uL solution of Renin Substrate, opening Q1 resolution to transmit all precursor isotopes of m/z 880, and resolving isotopes of singly charged ions at unit resolution in Q3 [0.7 -- 0.8 u FWHH. Mass accuracy be 0.01% over entire mass range, MS/MS transmission includes: while infusing 1 picomole/uL reserpine at 5 uL/min, the sum of all MS/MS product ions [including unfragmented parent ion] will not be less than original presursor ion intensity measured under MS/MS conditions [Q1 and Q3] resolving together but without collision gas. Q3 shall be operated at unit mass resolution [0.7 -- 0.8 u FWHH]. Divert value shall be under data system control, built-in syringe pump, differentially pumped vacuum syste with air-cooled turbomolecular pumps, fail-safe vacuum protection with automatic shutdown and restart after power failure. Interface shall be direct atmosphere-to-vacuum interface with curtain gas for declustering solvent droplets, capable of analyzing large batches of complex urine, plasma, plant or tissue estracts over long periods of time without maintenance or performance degradation. No heated capillary or complex apertures or lenses in the interface, to maintain structural integrity of analytes. Discrete dynote electron multiplier detector operated in the pulse counting mode and capable of very fast switching between positive and negative ion detection in alternate scans. Data system control of commercially available LC pumps and autosamplers, dynamic range shall be 1 cps to 4 X 10 6 cps [pulse counting], source operating on electrospray principals including: off axis-spray configuration, ionization voltage +/- 6kV, flow rate compatibility 2-1000 uL/min, ambient nebulizer gas temperature, drying gas perpendicular to spray trajectory [flow and temperature, up to 500 C, under operator control]. All ion source parameters are under computer control, 80 femtomoles reserpine introduced through the electrospray inlet at 40 uL/min will produce signal-to-noice of at least 10:1, monitoring m/z 609 in Q1 in S1M mode, input for analog output from any detector for acquisition simultaneous with mass spectral acquisiton, graphic user interface, multipane windows, full multitasking, fast alternate MS CID.MS [5 msec changover], library generation and search program, fully automated 96 microtitre plate samples runs and grahic data analysis report, direct transfer of sample batch information from Excel or other text editor to API acquisition software, fully automated. Solicitation package will be availble on or about August 1, 1998. Written requests shall be forwarded to the above address. Posted 07/15/98 (W-SN223498). (0196)

Loren Data Corp. http://www.ld.com (SYN# 0551 19980717\66-0020.SOL)