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COMMERCE BUSINESS DAILY ISSUE OF AUGUST 10,1998 PSA#2155U.S. Environmental Protection Agency, National Center for Environmental
Assessment (MS117), 26 West Martin Luther King Drive, Cincinnati, OH
45268 A -- RISK ASSESSMENT RESEARCH IN STATISTICAL TESTING AND MODELING TO
IMPROVE HUMAN HEALTH RISK ESTIMATION FROM EXPOSURE TO MIXTURES OF
DISINFECTION BY-PRODUCTS IN DRINKING WATER SOL NCEA-CIN-05 DUE 091598
POC Donna Tucker, FAX No. (513)569-7475 E-MAIL: Click here to e-mail
EPA Contact, tucker.donna@epamail.epa.gov. RISK ASSESSMENT RESEARCH IN
STATISTICAL TESTING AND MODELING TO IMPROVE HUMAN HEALTH RISK
ESTIMATION FROM EXPOSURE TO MIXTURES OF DISINFECTION BY-PRODUCTS IN
DRINKING WATER. -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- --
-- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- --
-- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Project Synopsis:
The U.S. Environmental Protection Agency, National Center for
Environmental RISK ASSESSMENT RESEARCH IN STATISTICAL TESTING AND
MODELING TO IMPROVE HUMAN HEALTH RISK ESTIMATION FROM EXPOSURE TO
MIXTURES OF DISINFECTION BY-PRODUCTS IN DRINKING WATER. -- -- -- -- --
-- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- — -- -- -- --
-- -- -- -- -- -- -- -- -- -- -- -- -- Project Synopsis: The U.S.
Environmental Protection Agency, National Center for Environmental
Assessment, Cincinnati Office (NCEA-Cincinnati) seeks proposals for
cooperative agreements to conduct statistical research related to the
improvement of human health risk assessment methodologies for both
cancer and non-cancer toxicity from exposure to mixtures of
disinfection by-products (DBPs) in drinking water. Proposals should
describe the statistical research to be conducted in collaboration with
investigators who are currently collecting laboratory toxicity data or
are willing to make existing laboratory data on mixtures of DBPs
available. The effort can be associated with an ongoing effort of the
U.S. EPA or the proposal writer may choose to conduct the research in
collaboration with other laboratory investigators outside of the U.S.
EPA. Because few statistical methods are available to successfully
analyze laboratory toxicity data on chemical mixtures, areas of
interest include: development of novel methods for the design and
analysis of laboratory experiments on mixtures of DBPs; establishment
of either the toxicity or interaction threshold values for mixtures of
DBPs; characterization of the nature or magnitude of interaction
effects including additivity, synergism and antagonism; and use of data
on individual or selected DBPs to estimate risk for the whole mixture.
EPA scientists expect to collaborate significantly in the research by
providing access to laboratory toxicity data and exposure information
on DBPs, collaborating on statistical methods and theory and on the
biological sciences, supplying expertise on chemical mixtures health
risk assessment, and participating in co-authorship of research
publications; therefore proposals should clearly identify an EPA role
as well as the role of the proposal writer and institution. The intent
of this application process is to develop one or more three-year
cooperative agreements where the principal purpose is to provide
support and stimulation to further scientific understanding in this
area of research. Through September 15, 1998, written requests only
will be taken to obtain a detailed solicitation package. Proposals must
be received by October 30, 1998 and submitted in accordance with the
solicitation package. Proposals will be thoroughly reviewed and
evaluated by guidelines as set forth in the solicitation package.
Depending on funding availability, the awards are estimated to range
from $100,000 to $300,000 total over three years. The U.S. EPA reserves
the right not to make any awards from this RFA. Interested applicants
must be eligible to receive Federal Assistance under the Clean Water
Act (CWA), Section 104(b)3, the Safe Drinking Water Act (SDWA), Section
1442, and the Safe Drinking Water Act Amendments (SDWAA) of 1996. ONLY
STATE AND LOCAL GOVERNMENTS, NONPROFIT RESEARCH INSTITUTIONS OF HIGHER
EDUCATION, INDIVIDUALS, OR NONPROFIT RESEARCHORGANIZATIONS ELIGIBLE TO
RECEIVE FEDERAL ASSISTANCE UNDER THESE ACTS SHOULD SUBMIT
APPLICATIONS. Proposals from other Federal Agencies are not solicited
and will not be accepted. Interested parties may obtain a copy of
Solicitation #NCEA-CIN-05 by contacting Donna Tucker, USEPA, National
Center for Environmental Assessment -- Cincinnati Office, MS-117, 26 W.
ML King Dr., Cincinnati, Ohio 45268, FAX: 513-569-7475, or email at
tucker.donna@epamail.epa.gov postmarked no later than September 15,
1998. ORAL REQUESTS WILL NOT BE ACCEPTED. Posted 08/06/98 (W-SN233440).
(0218) Loren Data Corp. http://www.ld.com (SYN# 0003 19980810\A-0003.SOL)
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