U.S. Environmental Protection Agency, National Center for Environmental Assessment (MS117), 26 West Martin Luther King Drive, Cincinnati, OH 45268

A -- RISK ASSESSMENT RESEARCH IN STATISTICAL TESTING AND MODELING TO IMPROVE HUMAN HEALTH RISK ESTIMATION FROM EXPOSURE TO MIXTURES OF DISINFECTION BY-PRODUCTS IN DRINKING WATER SOL NCEA-CIN-05 DUE 091598 POC Donna Tucker, FAX No. (513)569-7475 E-MAIL: Click here to e-mail EPA Contact, tucker.donna@epamail.epa.gov. RISK ASSESSMENT RESEARCH IN STATISTICAL TESTING AND MODELING TO IMPROVE HUMAN HEALTH RISK ESTIMATION FROM EXPOSURE TO MIXTURES OF DISINFECTION BY-PRODUCTS IN DRINKING WATER. -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Project Synopsis: The U.S. Environmental Protection Agency, National Center for Environmental RISK ASSESSMENT RESEARCH IN STATISTICAL TESTING AND MODELING TO IMPROVE HUMAN HEALTH RISK ESTIMATION FROM EXPOSURE TO MIXTURES OF DISINFECTION BY-PRODUCTS IN DRINKING WATER. -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- — -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Project Synopsis: The U.S. Environmental Protection Agency, National Center for Environmental Assessment, Cincinnati Office (NCEA-Cincinnati) seeks proposals for cooperative agreements to conduct statistical research related to the improvement of human health risk assessment methodologies for both cancer and non-cancer toxicity from exposure to mixtures of disinfection by-products (DBPs) in drinking water. Proposals should describe the statistical research to be conducted in collaboration with investigators who are currently collecting laboratory toxicity data or are willing to make existing laboratory data on mixtures of DBPs available. The effort can be associated with an ongoing effort of the U.S. EPA or the proposal writer may choose to conduct the research in collaboration with other laboratory investigators outside of the U.S. EPA. Because few statistical methods are available to successfully analyze laboratory toxicity data on chemical mixtures, areas of interest include: development of novel methods for the design and analysis of laboratory experiments on mixtures of DBPs; establishment of either the toxicity or interaction threshold values for mixtures of DBPs; characterization of the nature or magnitude of interaction effects including additivity, synergism and antagonism; and use of data on individual or selected DBPs to estimate risk for the whole mixture. EPA scientists expect to collaborate significantly in the research by providing access to laboratory toxicity data and exposure information on DBPs, collaborating on statistical methods and theory and on the biological sciences, supplying expertise on chemical mixtures health risk assessment, and participating in co-authorship of research publications; therefore proposals should clearly identify an EPA role as well as the role of the proposal writer and institution. The intent of this application process is to develop one or more three-year cooperative agreements where the principal purpose is to provide support and stimulation to further scientific understanding in this area of research. Through September 15, 1998, written requests only will be taken to obtain a detailed solicitation package. Proposals must be received by October 30, 1998 and submitted in accordance with the solicitation package. Proposals will be thoroughly reviewed and evaluated by guidelines as set forth in the solicitation package. Depending on funding availability, the awards are estimated to range from $100,000 to $300,000 total over three years. The U.S. EPA reserves the right not to make any awards from this RFA. Interested applicants must be eligible to receive Federal Assistance under the Clean Water Act (CWA), Section 104(b)3, the Safe Drinking Water Act (SDWA), Section 1442, and the Safe Drinking Water Act Amendments (SDWAA) of 1996. ONLY STATE AND LOCAL GOVERNMENTS, NONPROFIT RESEARCH INSTITUTIONS OF HIGHER EDUCATION, INDIVIDUALS, OR NONPROFIT RESEARCHORGANIZATIONS ELIGIBLE TO RECEIVE FEDERAL ASSISTANCE UNDER THESE ACTS SHOULD SUBMIT APPLICATIONS. Proposals from other Federal Agencies are not solicited and will not be accepted. Interested parties may obtain a copy of Solicitation #NCEA-CIN-05 by contacting Donna Tucker, USEPA, National Center for Environmental Assessment -- Cincinnati Office, MS-117, 26 W. ML King Dr., Cincinnati, Ohio 45268, FAX: 513-569-7475, or email at tucker.donna@epamail.epa.gov postmarked no later than September 15, 1998. ORAL REQUESTS WILL NOT BE ACCEPTED. Posted 08/06/98 (W-SN233440). (0218)

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