National Cancer Institute, Research Contracts Branch, PSAS, 6120 Executive Blvd, EPS/Room 638, Bethesda, MD 20892-7227

A -- FRAMINGHAM CANCER FILE UPDATE II SOL RFQ80220(NR) DUE 091698 POC Marsha Gorham, Purchasing Agent, (301)402-4509 & Todd Cole, Contracting Officer The Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute plans to procure the services of the Trustees of Boston University, Boston University Medical Campus, 80 E. Concord Street, Boston, MA 02118. The Framingham Heart Study is an ongoing prospective study initiated in 1948 to identify risk factors for cardiovascular disease. Data are collected biannually from the 5,209 study participants on a variety of characteristics including weight and other anthropometric measures, reproductive history, smoking, alcohol ingestion, physical activity, and medications including exogenous hormones. Extensive diet histories also were collected from 900 men early in the study. Blood was drawn at each visit and data on numerous biochemical indices also are available. The Offspring Study was initiated in 1971 to facilitate evaluation of genetic hypotheses. NCI initially contracted with Boston University in 1985 for a computer file of cancer cases diagnosed in the Framingham Heart Study and Offspring Study. NCI awarded a second contract to Boston University in 1994 to update the cancer files through updated exams and cycles for the cohort and offspring studies, respectively. Current files include data on 1,934 cancers diagnosed in cohort members and 684 cancers diagnosed among the offspring. These data have been used collaboratively by NCI, Framingham and Boston University staff, to evaluate relationships of body size, alcohol ingestion, physical activity, and bone density to breast cancer risk, parental age at birth to prostate cancer risk, and physical activity to colon cancer risk. The Framingham Heart Study and Offspring Study contain a wealth of information on exposures potentially related to cancer. The usefulness of these data increases as the number of cancer diagnoses grows. The Government's Framingham Cancer File Update is necessary so the usefulness of the Framingham Heart Study and the Offspring Study to evaluate etiologic hypotheses for cancer remains current and up-to-date since 1994. Since Boston University has all rights to the data on cancer among members of the Framingham Heart Study and Offspring Study, it is the only source known to NCI that can meet the requirements of updating the data that NCI already has available from the Framingham studies. If any interested party believes it can perform the above work and maintain the reliability of all data, it may submit a statement of capabilities. The statement of capabilities and any other information furnished must be in writing and must contain material in sufficient detail to allow NCI to determine if the party can perform this requirement. Capability statements must be received in the contracting office by 3:00 p.m. EST, on September 16, 1998. If you have any questions, please contact Marsha Gorham, Purchasing Agent on (301)402-4509. A determination by the Government not to compete this proposed requirement based upon responses to this notice is solely within the discretion of the Government. Informationreceived will be considered solely for the purpose of determining whether to conduct a competitive procurement. Posted 08/28/98 (W-SN243471). (0240)

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