National Cancer Institute, Research Contracts Branch, PSAS, 6120 Executive Blvd, EPS/Room 638, Bethesda, MD 20892-7227

66 -- INSTRUMENTS & LABORATORY EQUIPMENT SOL RFQ-NCI-80224 DUE 092198 POC Cynthia Brown, Purchasing Agent, 301-402-4509, Todd Cole, Contracting Officer The National Institutes of Health, National Cancer Institutes, Division of Clinical Sciences, Laboratory of Pathology, intends to procure one(1) CytoVision Karyotyper Workstation with accessories from Applied Imaging, Robinson Plaza II Suite 140, Route 60, Pittsburgh, Pa., 15205. This s a combined sole source synopsis/solicitation for commercial items prepared in accordance with the format in the Federal Acquisition Regulation (FAR) 12.6, as supplemented by additional information included in this notice. This announcement constitutes the only solicitation and a separate written solicitation will not be issued. The solicitation includes all applicable provisions and clauses in effect through FAR FAC 97-05. The acquisition is being made in accordance with the test program for simplified procedures for certain commercial items authorized in FAR 13.5. The Standard Industrial Classification Code is 3845 and the business size standard is 500 employees. However, this requirement is not set-aside for small business. BACKGROUND: The Laboratory of Pathology provides services and opportunities for collaborative research to investigators throughout the NCI as well as other NIH Institutes. Services include a variety of tests for the detection of constitutional (ie., congenital) and acquired chromosomal abnormalities. The CytoVision Workstation will be used to perform three critical functions. First, the standard in cytogenetics has been, and continues to be, high-resolution G- banded karyotype analysis. This methodology allows for the detection of numerical and structural chromosomal abnormalities at the level of the light microscope. Second, recent developments in fluorescence in -situ hybridization (FISH) technology have made it possible to see submicroscopic chromosomal changes in both actively-dividing (mitotic) and resting (interphase) cells. Third, comparative genomic hybridization (CGH), which also uses FISH techniques, has very recently emerged as a powerful technology for investigating gains and losses of chromosomal material throughout the genome in tissue that has been fixed and/or stores. CGH thus adds a new dimension to our research program in molecular cytogenetics investigations of tumor initiation and progression. This system will be hooded into the current CytoVision Ultra Fish main system which includes optical disc storage of records, a color printer, and a plain paper laser printer. Applied Imaging is the only known source to NCI that can provide a second "remote" workstation that is compatible with our current system. The new workstation must be capable of image analysis, documentation, and storage of all three types of records as indicated above. B.) REQUIREMENTS-The CytoVision Karyotyper WorkstationApplied Imaging shall include the following: 1.)Intel Pentium UNIX-based computer workstation, imaging capture facility, integrating CCD camera, 12 position excitation filter wheel and comprehensive filter set, 100 MB ZIP drive, 3.5" floppy disk drive, 17" color monitor, keyboard, mouse, Operator's manualand license to use Probe and CGH software. 2.) Full one year comprehensive warranty and travel costs for repairs and software upgrades during the warranty period; and 3) full user training by an application specialist at the time of installation. The hardware and software included in this computerized image analysis system must provide G-banded karyotyping, FISH, and CGH capabilities. NOTE: All equipment must be Year 2000 Compliance. Delivery shall be made F.O.B. Destination, inside delivery, no later than 60 days after receipt of order to the National Cancer Institute, Division of Clinical Sciences, 9000 Rockville Pike, Bldg. 10, Rm. 3C731, Rockville, MD. 20892. C).PROVISIONS AND CLAUSES:: The solicitation incorporates the provisions at FAR 52.212-1, INSTRUCTIONS TO OFFERORS-COMMERCIAL ITEMS, and at FAR 52.212-3, OFFEROR REPRESENTATIONS AND CERTIFICATIONS -COMMERCIAL ITEMS. The latter provision includes the DUNS Number addendum. The resulting contract will incorporate the requirements of the clause at FAR 52.212-4, CONTRACT TERMS AND CONDITIONS-COMMERCIAL ITEMS with Year 2000 Addendum, and the requirements contained in paragraphs (a) and (d) of the clause at FAR 52.212-5, CONTRACT TERMS AND CONDITIONS REQUIRED TO IMPLEMENT STATUTES OR EXECUTIVE ORDERS -- COMMERCIAL ITEMS -- DEVIATION FOR SIMPLIFIED ACQUISITIONS. The following FAR clauses cited in paragraph (b) of the clause at FAR 52.212-5 are also applicable to this acquisition: FAR 52.222-26, EQUAL OPPORTUNITY; FAR 52.222-35, AFFIRMATIVE ACTION FOR SPECIAL DISABLED AND VIETNAM ERA VETERANS; FAR 52.222-36, AFFIRMATIVE ACTION FOR WORKERS WITH DISABILITIES; FAR 52.222.37, EMPLOYMENT REPORTS ON SPECIAL DISABLED VETERANS AND VETERANS OF VIETNAM ERA; and FAR 52.225- 3, BUY AMERICAN ACT -- SUPPLIES. Full text copies of the Representations and Certifications or other cited provisions and clauses may be obtained from Cynthia Brown on (301) 402-4509. D.) OFFERS: Applied Imaging is the only known source to NCI that can meet the requirements and provide compatibility and comparability to the existing CytoVision Karyotyper Workstation, with a full one year comprehensive warranty as indicated. This is not a solicitation for competitive proposals, However, if any other interested party believes it can meet NCI's needs, it may submit an offer to Cynthia Brown at the address cited above. Your offer must meet all requirements specified herein, including the capabilities and features specified herein, including the capabilities identified in the above paragraph. Offers must be submitted on an SF-18 or SF-1449 that is signed by an authorized representative of the offeror and includes a completed "Schedule of Offered Supplies/Services." Offers must be accompanied descriptive literature, warranties, and/or other material that demonstrate that the offer meets the stated requirements. Offers and related materials must be received in the contracting office by 3:00 p.m. EST on Sept.21, 1998. No collects calls will be accepted. Please cite the solicitation number. RFQ-NCI-80224 onyour offer. Posted 09/03/98 (W-SN245403). (0246)

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