National Institutes of Environmental Health Sciences, Research Contracts Branch, DERT, P.O. Box 12874, Building 4401, Research Commons, 79 T.W. Alexander Drive, Research Triangle Park, NC 27709

A -- STUDIES OF CHEMICAL DISPOSITON IN MAMMALS SOL NIH-ES-98-29 DUE 112098 POC Howard Hill, Contract Specialist, (919)541-4971, Allan Benton Contracting Officer (919)541-4670 WEB: NONE, NONE. E-MAIL: NONE, NONE. The purpose of this project is to obtain detailed chemical disposition data from 3 to 6 studies per year of selected environmental contaminants or model compounds per year. Most of these studies will be required in laboratory rats and/or mice; however, some studies may be required in other laboratory animals (rodents or dogs). Offerors should note that in year one and in subsequent years, most studies will involve rats (Fischer 344) and/or mice (B6C3F1). For costing purposes offerors are to include costs for one study using purebred beagle dogs purchased from a commercial breeder of laboratory animals in year one, only. Most studies will address the disposition of organic chemicals or environmental contaminants; however, studies of inorganic compounds may also be requested. Individual studies may vary in complexity from preliminary investigations of chemical absorption to detailed studies of all phases of chemical disposition, toxicokinetics, and metabolism. The immediate goal of these studies is to determine more accurately the doses for NTP bioassay studies. The long-range goal is the accumulation of data that will permit a better assessment of structure-activity relationships chemical absorption, metabolism and disposition in laboratory animals and to better interpret the significance of these data to man. This project will cover a five year period. The government estimates that the project will require approximately 2.0 professional person-years and 3.0 technical person years per contract year. All requests must reference RFP No. 98-29 and must be directed to the office listed above. All responsible sources may submit a proposal which shall be considered by the Agency. Posted 09/16/98 (W-SN250642). (0259)

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